Shopping Cart

Your shopping cart is currently empty

(R)-Fangchinoline

Name: (R)-Fangchinoline
Brand: TargetMol
SKU: T2809
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T2809Cas No. 33889-68-8

Alias Thaligine, Demethyl tetrandrine, (+)-Thalrugosine

(R)-Fangchinoline ((+)-Thalrugosine) is extracted from Stephania tetrandra S. Moore.

(R)-Fangchinoline

Copy Product Info

😃Good

Purity: 99.83%

Catalog No. T2809Alias Thaligine, Demethyl tetrandrine, (+)-ThalrugosineCas No. 33889-68-8

(R)-Fangchinoline ((+)-Thalrugosine) is extracted from Stephania tetrandra S. Moore.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$48	In Stock	In Stock
50 mg	$68	In Stock	In Stock
100 mg	$98	In Stock	In Stock
200 mg	$142	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.83%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

(R)-Fangchinoline AI Summary

(R)-Fangchinoline exhibits notable cytotoxicity and antimalarial activity. It demonstrates cytotoxicity against multiple cell lines, including mouse P388 cells (ED50 of 0.36 μg/ml), human multidrug-sensitive KB3 cells (ED50 of 3.4 μg/ml), and human multidrug-resistant KBV1 cells (ED50 of 11.0 μg/ml). Additionally, the compound shows cytotoxicity against other human cell lines such as BCA1, HT1080, LUC1, SK-MEL-2, COL1, KB, KB-V1, A431, LNCAP, and ZR-75-1 with ED50 values ranging from 1.2 to 14.9 μg/ml. In terms of antimalarial activity, (R)-Fangchinoline is effective against both chloroquine-sensitive Plasmodium falciparum D6 and chloroquine-resistant Plasmodium falciparum W2 strains. For the D6 strain, it has an ED50 of 65.1 ng/ml and an IC50 of 199.0 nM, showing a selectivity index of 54.0. For the W2 strain, it has an ED50 of 78.0 ng/ml and an IC50 of 378.0 nM, with a selectivity index of 28.0. These properties indicate its potential for selective antimalarial therapy and broad-spectrum cytotoxicity against cancer cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(R)-Fangchinoline ((+)-Thalrugosine) is extracted from Stephania tetrandra S. Moore.
Synonyms	Thaligine, Demethyl tetrandrine, (+)-Thalrugosine

Chemical Properties

Molecular Weight	608.72
Formula	C₃₇H₄₀N₂O₆
Cas No.	33889-68-8
Smiles	COc1ccc2CC3N(C)CCc4cc(OC)c(O)c(Oc5cc6C(Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34
Relative Density.	1.204 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70.71 mg/mL (116.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6428 mL	8.2140 mL	16.4279 mL	82.1396 mL
5 mM	0.3286 mL	1.6428 mL	3.2856 mL	16.4279 mL
10 mM	0.1643 mL	0.8214 mL	1.6428 mL	8.2140 mL
20 mM	0.0821 mL	0.4107 mL	0.8214 mL	4.1070 mL
50 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6428 mL
100 mM	0.0164 mL	0.0821 mL	0.1643 mL	0.8214 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc