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Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $115 | Inquiry | Inquiry | |
| 10 mg | $189 | Inquiry | Inquiry | |
| 25 mg | $263 | Inquiry | Inquiry |
| Description | Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans. |
| In vitro | It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle and is essential for the G1/S transition. This protein associate with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. Its activity is also regulated by phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. The role of this protein in the G1-S transition has been recently questioned as cells lacking Cdk2 are reported to have no problem during this transition [2][3]. |
| Molecular Weight | 2571.05 |
| Formula | C111H196N48O23 |
| Smiles | N[C@@]([H])(C/C1=C/C=C(/O)C=C1)C(=O)NCC(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCCCN)C(=O)N[C@]([H])(CCCCN)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCC(N)=O)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)NCC(=O)N2CCC[C@]2([H])C(=O)N[C@@]([H])(C(=O)N[C@]([H])(CCCCN)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CC(C)(C)[H])C(=O)N[C@]([H])(C/C3=C/C=CC=C3)C(=O)NCC(O)=O)C(C)(C)[H] |
| Relative Density. | no data available |
| Sequence | Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly |
| Sequence Short | YGRKKRRQRRRGPVKRRLFG |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: ≥257.1 mg/mL, Sonication is recommended. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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