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Cdk2/Cyclin Inhibitory Peptide I

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Catalog No. TP2192

Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans.

Cdk2/Cyclin Inhibitory Peptide I

Cdk2/Cyclin Inhibitory Peptide I

😃Good
Catalog No. TP2192
Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$115InquiryInquiry
10 mg$189InquiryInquiry
25 mg$263InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans.
In vitro
It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle and is essential for the G1/S transition. This protein associate with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. Its activity is also regulated by phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. The role of this protein in the G1-S transition has been recently questioned as cells lacking Cdk2 are reported to have no problem during this transition [2][3].
Chemical Properties
Molecular Weight2571.05
FormulaC111H196N48O23
SmilesN[C@@]([H])(C/C1=C/C=C(/O)C=C1)C(=O)NCC(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCCCN)C(=O)N[C@]([H])(CCCCN)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCC(N)=O)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)NCC(=O)N2CCC[C@]2([H])C(=O)N[C@@]([H])(C(=O)N[C@]([H])(CCCCN)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(CC(C)(C)[H])C(=O)N[C@]([H])(C/C3=C/C=CC=C3)C(=O)NCC(O)=O)C(C)(C)[H]
Relative Density.no data available
SequenceTyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly
Sequence ShortYGRKKRRQRRRGPVKRRLFG
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: ≥257.1 mg/mL, Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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