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CIQ

Name: CIQ
Brand: TargetMol
SKU: T14971
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14971Cas No. 486427-17-2

CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit, with EC50 values of 2.7 μM for NR2C and 2.8 μM for NR2D.

CIQ

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Purity: 99.5%

Catalog No. T14971Cas No. 486427-17-2

CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit, with EC50 values of 2.7 μM for NR2C and 2.8 μM for NR2D.

Pack Size	Price	Availability
2 mg	$29	In Stock
5 mg	$46	In Stock
10 mg	$76	In Stock
25 mg	$148	In Stock
50 mg	$221	In Stock
100 mg	$326	In Stock
1 mL x 10 mM (in DMSO)	$49	In Stock

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Batch Information

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Purity:99.5%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit, with EC50 values of 2.7 μM for NR2C and 2.8 μM for NR2D.
Targets&IC50	NR2C:2.7 μM(EC50), NR2D:2.8 μM(EC50)
In vitro	CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinson's disease models. NMDA receptor CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively). It has no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses.

Chemical Properties

Molecular Weight	467.94
Formula	C₂₆H₂₆ClNO₅
Cas No.	486427-17-2
Smiles	COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1
Relative Density.	1.238 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (106.85 mM), Sonication is recommended.

H2O: insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1370 mL	10.6851 mL	21.3703 mL	106.8513 mL
5 mM	0.4274 mL	2.1370 mL	4.2741 mL	21.3703 mL
10 mM	0.2137 mL	1.0685 mL	2.1370 mL	10.6851 mL
20 mM	0.1069 mL	0.5343 mL	1.0685 mL	5.3426 mL
50 mM	0.0427 mL	0.2137 mL	0.4274 mL	2.1370 mL
100 mM	0.0214 mL	0.1069 mL	0.2137 mL	1.0685 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc