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Coixol

Name: Coixol
Brand: TargetMol
SKU: T2S2108
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S2108Cas No. 532-91-2

Alias MBOA, 6-methoxybenzoxazolone, 6-Methoxy-2-benzoxazolinone, 6-MBOA

1. Coixol (MBOA) acts as a central muscle relaxant with an anti-convulsant effect. 2. Coixol interacts with the pituitary to stimulate reproduction in voles. 3. Coixol has the ability to interact with FSH to stimulate follicular development and increase ovulation. 4. Coixol can regulate gene expression, production and secretion of mucin, by directly acting on airway epithelial cells.

Coixol

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Purity: 99.98%

Catalog No. T2S2108Alias MBOA, 6-methoxybenzoxazolone, 6-Methoxy-2-benzoxazolinone, 6-MBOACas No. 532-91-2

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$39	In Stock	In Stock
50 mg	$57	In Stock	In Stock
100 mg	$83	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Coixol AI Summary

Coixol exhibits multiple bioactivities, including significant anti-inflammatory, antioxidant, cytoprotective, and insecticidal effects. In Wistar rat peritoneal mast cells, it inhibits IgE-induced histamine release by 40.0% and concanavalin A-induced histamine release by 47.3%, with an IC50 value of 1.0 x 10^-3 M for the latter. Additionally, it inhibits CuSO4-induced human LDL oxidation, prolonging the lag phase of conjugated diene formation, and provides cytoprotection against minimally oxidized LDL-induced cytotoxicity in BAEC, as indicated by 90.0% cell viability post-treatment. Furthermore, Coixol demonstrates insecticidal activity against Sitobion avenae apterous virginoparous nymphs, particularly at lower concentrations, with the most significant suppression of the insects' intrinsic reproduction rate observed at 0.1 mM concentration after 4 weeks of exposure..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Coixol (MBOA) acts as a central muscle relaxant with an anti-convulsant effect. 2. Coixol interacts with the pituitary to stimulate reproduction in voles. 3. Coixol has the ability to interact with FSH to stimulate follicular development and increase ovulation. 4. Coixol can regulate gene expression, production and secretion of mucin, by directly acting on airway epithelial cells.
Synonyms	MBOA, 6-methoxybenzoxazolone, 6-Methoxy-2-benzoxazolinone, 6-MBOA

Chemical Properties

Molecular Weight	165.15
Formula	C₈H₇NO₃
Cas No.	532-91-2
Smiles	COc1ccc2[nH]c(=O)oc2c1
Relative Density.	1.309g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (302.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0551 mL	30.2755 mL	60.5510 mL	302.7551 mL
5 mM	1.2110 mL	6.0551 mL	12.1102 mL	60.5510 mL
10 mM	0.6055 mL	3.0276 mL	6.0551 mL	30.2755 mL
20 mM	0.3028 mL	1.5138 mL	3.0276 mL	15.1378 mL
50 mM	0.1211 mL	0.6055 mL	1.2110 mL	6.0551 mL
100 mM	0.0606 mL	0.3028 mL	0.6055 mL	3.0276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc