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S-Gboxin

Name: S-Gboxin
Brand: TargetMol
SKU: T5335
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5335Cas No. 2101317-21-7

S-Gboxin is an active analogue of Gboxin with potent antitumour activity. S-Gboxin inhibits the growth of mouse and human glioblastoma (GBM, IC50: 470 nM).

S-Gboxin

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Purity: 99.32%

Catalog No. T5335Cas No. 2101317-21-7

S-Gboxin is an active analogue of Gboxin with potent antitumour activity. S-Gboxin inhibits the growth of mouse and human glioblastoma (GBM, IC50: 470 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
2 mg	$142	In Stock	In Stock
5 mg	$239	In Stock	In Stock
10 mg	$347	In Stock	In Stock
25 mg	$589	In Stock	In Stock
50 mg	$816	In Stock	In Stock
100 mg	$1,070	In Stock	In Stock
200 mg	$1,450	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$316	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.32%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

S-Gboxin AI Summary

S-Gboxin shows a half-life of 15.15 hours in CD1 mouse plasma after intraperitoneal administration at 10 mg/kg, reaching a maximum concentration (Cmax) of 375.0 ng/g under these conditions, as determined by LC/MS/MS analysis. Additionally, when incubated in mouse plasma for up to 1440 minutes, it has a half-life of 5.1 hours based on mass spectrometric analysis. The compound also demonstrates anticancer activity against human GBM cells, indicated by a reduction in cell viability after 96 hours of incubation, measured using the Cell-Titer-Glo assay. It exhibits an IC50 value of 470.0 nM, reflecting its potency in inhibiting the growth of GBM cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	S-Gboxin is an active analogue of Gboxin with potent antitumour activity. S-Gboxin inhibits the growth of mouse and human glioblastoma (GBM, IC50: 470 nM).
Targets&IC50	GBM:470 nM

Chemical Properties

Molecular Weight	600.46
Formula	C₂₇H₃₂F₃IN₂O₂
Cas No.	2101317-21-7
Smiles	[I-].CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C[n+]1c(-c2cccc(c2)C(F)(F)F)n(C)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 85 mg/mL (141.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 8 mg/mL (13.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6654 mL	8.3269 mL	16.6539 mL	83.2695 mL
5 mM	0.3331 mL	1.6654 mL	3.3308 mL	16.6539 mL
10 mM	0.1665 mL	0.8327 mL	1.6654 mL	8.3269 mL
20 mM	0.0833 mL	0.4163 mL	0.8327 mL	4.1635 mL
50 mM	0.0333 mL	0.1665 mL	0.3331 mL	1.6654 mL
100 mM	0.0167 mL	0.0833 mL	0.1665 mL	0.8327 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc