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CZC-54252

Name: CZC-54252
Brand: TargetMol
SKU: T2022
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2022Cas No. 1191911-27-9

Alias CZC54252, CZC 54252

CZC-54252 is a potent inhibitor of LRRK2.

CZC-54252

🥰Excellent

Purity: 99.39%

Catalog No. T2022Alias CZC54252, CZC 54252Cas No. 1191911-27-9

CZC-54252 is a potent inhibitor of LRRK2.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$45	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$228	In Stock	-
50 mg	$346	In Stock	-
1 mL x 10 mM (in DMSO)	$81	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.39%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	CZC-54252 is a potent inhibitor of LRRK2.
Targets&IC50	LRRK2 (G2019S):1.85 nM (IC50), LRRK2 (wild-type):1.28 nM (IC50)
Synonyms	CZC54252, CZC 54252

Chemical Properties

Molecular Weight	504.99
Formula	C₂₂H₂₅ClN₆O₄S
Cas No.	1191911-27-9
Smiles	COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
Relative Density.	1.452 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9802 mL	9.9012 mL	19.8024 mL	99.0119 mL
5 mM	0.3960 mL	1.9802 mL	3.9605 mL	19.8024 mL
10 mM	0.1980 mL	0.9901 mL	1.9802 mL	9.9012 mL
20 mM	0.0990 mL	0.4951 mL	0.9901 mL	4.9506 mL
50 mM	0.0396 mL	0.1980 mL	0.3960 mL	1.9802 mL
100 mM	0.0198 mL	0.0990 mL	0.1980 mL	0.9901 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc