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L-Canavanine sulfate

Name: L-Canavanine sulfate
Brand: TargetMol
SKU: T5838
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5838Cas No. 2219-31-0

L-Canavanine sulfate is a selective inducible NO synthase inhibitor.

L-Canavanine sulfate

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Purity: 99.73%

Catalog No. T5838Cas No. 2219-31-0

L-Canavanine sulfate is a selective inducible NO synthase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.73%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	L-Canavanine sulfate is a selective inducible NO synthase inhibitor.
In vitro	L-Canavanine sulfate,which is hardly toxic alone, potentiated the cytotoxicity of VIN and PTX in HeLa and hepatocellular carcinoma cells[1].
In vivo	Intravenous infusion of L-canavanine (100 mg/kg), a selective inhibitor of inducible NO synthase in vitro, 60 min and 180 min after lipopolysaccharide challenge, produced an increase in mean arterial pressure and reversed the lipopolysaccharide induced hypotension. However, in lipopolysaccharide challenged animals protected from hypotension by administration of L-canavanine (60 min post challenge), intravenous infusion of NG-nitro-L-arginine methyl ester at 180 min post challenge caused an immediate rise in mean arterial pressure, followed by a rapid fall in blood pressure and heart rate, and sudden death. In contrast, a second dose of L-canavanine at 180 min post challenge maintained blood pressure for the duration of the experiment. Inhibition of both constitutive and inducible NO synthase during endotoxaemia is lethal[2].
Cell Research	The following cancer cells grown in arginine-rich and arginine-free media were employed: HeLa, Hep G2 and SK-HEP-1. Drug combination experiment used a method based on the median-effect principle and mass-action law[1].

Chemical Properties

Molecular Weight	274.25
Formula	C₅H₁₄N₄O₇S
Cas No.	2219-31-0
Smiles	OS(O)(=O)=O.N[C@@H](CCONC(N)=N)C(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 125 mg/mL (455.79 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.6463 mL	18.2315 mL	36.4631 mL	182.3154 mL
5 mM	0.7293 mL	3.6463 mL	7.2926 mL	36.4631 mL
10 mM	0.3646 mL	1.8232 mL	3.6463 mL	18.2315 mL
20 mM	0.1823 mL	0.9116 mL	1.8232 mL	9.1158 mL
50 mM	0.0729 mL	0.3646 mL	0.7293 mL	3.6463 mL
100 mM	0.0365 mL	0.1823 mL	0.3646 mL	1.8232 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc