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Isotrifoliin

Name: Isotrifoliin
Brand: TargetMol
SKU: T4902
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4902Cas No. 21637-25-2

Alias Isoquercitroside, Isoquercetin

Isotrifoliin (Isoquercitroside)n is an effective antioxidant and an eosinophilic inflammation suppressor.

Isotrifoliin

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Purity: 99.45%

Catalog No. T4902Alias Isoquercitroside, IsoquercetinCas No. 21637-25-2

Isotrifoliin (Isoquercitroside)n is an effective antioxidant and an eosinophilic inflammation suppressor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	-	In Stock
10 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$43	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.45%

Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Isotrifoliin (Isoquercitroside)n is an effective antioxidant and an eosinophilic inflammation suppressor.
In vitro	Isoquercitrin occurs widely in plants.10 μM of Isoquercitrin of the seven compounds partially but significantly blunt the negative effect of H2O2 on RGC-5 cells, as the viability of cells in the presence of H2O2 is increased from approximately 63% to 83% and 90% at 10 and 50 μM, respectively. Indeed, 50 μM Isoquercitrin is more effective as a neuroprotectant than the same concentration of EGCG.
In vivo	In animal studies, both Isoquercitrin and quercetin administration resulted in reduced eosinophil counts in the bronchoalveolar lavage fluid (BALF), blood, and lung parenchyma. Isoquercitrin-treated mice uniquely exhibited decreased neutrophil counts in blood and lower IL-5 concentrations in lung homogenates. No significant changes were observed in mononuclear cell counts.
Synonyms	Isoquercitroside, Isoquercetin

Chemical Properties

Molecular Weight	464.38
Formula	C₂₁H₂₀O₁₂
Cas No.	21637-25-2
Smiles	OC[C@@H](O)[C@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)[C@H](O)[C@H]1O
Relative Density.	1.87g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (269.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1534 mL	10.7670 mL	21.5341 mL	107.6704 mL
5 mM	0.4307 mL	2.1534 mL	4.3068 mL	21.5341 mL
10 mM	0.2153 mL	1.0767 mL	2.1534 mL	10.7670 mL
20 mM	0.1077 mL	0.5384 mL	1.0767 mL	5.3835 mL
50 mM	0.0431 mL	0.2153 mL	0.4307 mL	2.1534 mL
100 mM	0.0215 mL	0.1077 mL	0.2153 mL	1.0767 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc