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Bilirubin
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Catalog No. T2934Cas No. 635-65-4
Alias Principal bile pigment, Hemetoidin, Hematoidin, Bilibubin
Bilirubin (Principal bile pigment) is a type of bile pigment, which is a metabolite of hemoglobin in the blood. Bilirubin has antimutagenic and antioxidant effects. Bilirubin is an important basis for clinical determination of jaundice, and is also an important indicator of liver function.
Bilirubin
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Purity: 99.59%
Catalog No. T2934Alias Principal bile pigment, Hemetoidin, Hematoidin, BilibubinCas No. 635-65-4
Bilirubin (Principal bile pigment) is a type of bile pigment, which is a metabolite of hemoglobin in the blood. Bilirubin has antimutagenic and antioxidant effects. Bilirubin is an important basis for clinical determination of jaundice, and is also an important indicator of liver function.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $31 | In Stock | In Stock | |
| 50 mg | $42 | In Stock | In Stock | |
| 100 mg | $59 | In Stock | In Stock | |
| 500 mg | $138 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.59%
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Product Introduction
Bilirubin AI Summary
Bilirubin demonstrates moderate to high apparent permeability in human Caco-2 cells, particularly in the presence of BSA in the basolateral chamber, but exhibits low metabolic stability with BSA. It is bioactive in numerous assays, inhibiting Menin-MLL interaction, HSD17B4, Caspase-1 and -7, TDP1, Cruzain, Tau fibril formation, ALDH1A1, Bacillus subtilis Sfp phosphopantetheinyl transferase, and Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia, and modulating Lamin A splicing. It targets JMJD2E, IMPase with Lithium potentiation, and demonstrates specific enzyme activity with UGT1A1, showing minimal to no interaction with UGT1A4, -1A6, -1A9, -2B17, and -2B7 enzymes.
The compound exhibits transporter bioactivity in Xenopus laevis oocytes with Km values of 7.6 nM and 39.1 nM, and inhibits BSP uptake by 43.0%. It inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells with approximately 32.05% inhibition at 10 µM concentration (IC50: 3388.44 nM, Ki: 2630.0 nM) and in OATP1B1-transfected CHO cells with 15.29% inhibition at 10 µM (IC50: 1318.26 nM, Ki: 720.0 nM).
Bilirubin shows significant antimutagenic activity against PhIP-induced and aflatoxin B1-induced mutagenesis in Salmonella typhimurium, with 82.0% and 54.0% inhibition respectively, in the presence of S9 liver homogenate. Additionally, it exhibits mutagenic activity relative to aflatoxin B1 in TA98 assays with an activity of 352.0%.
Furthermore, it demonstrates antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells, with IC50 values greater than 20000.0 nM. Bilirubin retains stability of 44.0% after 24 hours under dark freezer conditions, as shown by LC-MS/MS analysis..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Bilirubin (Principal bile pigment) is a type of bile pigment, which is a metabolite of hemoglobin in the blood. Bilirubin has antimutagenic and antioxidant effects. Bilirubin is an important basis for clinical determination of jaundice, and is also an important indicator of liver function. |
| In vitro | METHODS: Hippocampal primary neurons were treated with Bilirubin (12-25 µM) for 24 h. Mitochondrial membrane potential (ΔΨm) was measured by JC-1 fluorescence staining.
RESULTS: Bilirubin treatment decreased ΔΨm in a dose-dependent manner. [1] METHODS: Neural stem cell NSC were treated with Bilirubin (6.25-50 µM) for 96 h. Cell viability was measured by MTT assay. RESULTS: Cell viability was significantly reduced after exposure to 50 µM Bilirubin concentration. The viability of cells exposed to Bilirubin was gradually and significantly reduced. [2] |
| In vivo | METHODS: To investigate the effects on atherosclerosis, Bilirubin (30 mg/kg, 50 mmol/L of K3PO4 plus 10% serum) was administered intraperitoneally to Ldlr-/- mice on Western diet once daily for eight weeks.
RESULTS: Bilirubin prevented atherosclerotic plaque formation but did not alter circulating cholesterol or chemokine levels. Bilirubin-treated animals had reduced lipid and collagen deposition in the aortic root, decreased monocyte and lymphocyte infiltration, fewer smooth muscle cells, decreased levels of chlorotyrosine and nitrotyrosine, and no changes in VCAM-1 or ICAM-1 expression. [3] |
| Synonyms | Principal bile pigment, Hemetoidin, Hematoidin, Bilibubin |
| Molecular Weight | 584.66 |
| Formula | C33H36N4O6 |
| Cas No. | 635-65-4 |
| Smiles | C(C1=C(CCC(O)=O)C(C)=C(/C=C\2/C(C=C)=C(C)C(=O)N2)N1)C3=C(CCC(O)=O)C(C)=C(/C=C\4/C(C)=C(C=C)C(=O)N4)N3 |
| Relative Density. | 1.374 g/cm3 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (15.39 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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