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CID 16020046

Name: CID 16020046
Brand: TargetMol
SKU: T4478
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4478Cas No. 834903-43-4

Alias C390-0219

CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.

CID 16020046

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Purity: 99.03%

Catalog No. T4478Alias C390-0219Cas No. 834903-43-4

CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.

Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$56	In Stock
10 mg	$81	In Stock
25 mg	$163	In Stock
50 mg	$239	In Stock
100 mg	$347	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Purity:99.03%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
Targets&IC50	GPR55:0.15 μM
In vitro	In yeast cells expressing human GPR55, CID16020046 inhibited agonist-induced receptor activation. In human embryonic kidney (HEK293) cells stably expressing human GPR55, CID16020046 behaved as an antagonist on LPI-mediated Ca2+ release and extracellular signal-regulated kinases activation, but not in HEK293 cells expressing cannabinoid receptor 1 or 2 (CB1 or CB2). CID16020046 dose-dependently inhibited lysophosphatidylinositol (LPI)-induced activation of nuclear factor of activated T-cells (NFAT), nuclear factor κ of activated B cells (NF-κB) and serum response element, translocation of NFAT and NF-κB, and GPR55 internalization [1].
Synonyms	C390-0219

Chemical Properties

Molecular Weight	425.44
Formula	C₂₅H₁₉N₃O₄
Cas No.	834903-43-4
Smiles	Cc1ccc(cc1)-c1n[nH]c2C(=O)N(C(c12)c1cccc(O)c1)c1ccc(cc1)C(O)=O
Relative Density.	1.425 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (129.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3505 mL	11.7525 mL	23.5051 mL	117.5254 mL
5 mM	0.4701 mL	2.3505 mL	4.7010 mL	23.5051 mL
10 mM	0.2351 mL	1.1753 mL	2.3505 mL	11.7525 mL
20 mM	0.1175 mL	0.5876 mL	1.1753 mL	5.8763 mL
50 mM	0.0470 mL	0.2351 mL	0.4701 mL	2.3505 mL
100 mM	0.0235 mL	0.1175 mL	0.2351 mL	1.1753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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