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alpha-Tocopherolquinone

Name: alpha-Tocopherolquinone
Brand: TargetMol
SKU: T7050
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7050Cas No. 7559-04-8

Alias Metarene

During hypoxia in rats, levels of α-tocopherylquinon have been found to rise. alpha-Tocopherolquinone (Metarene) is reported to downregulate the respiratory activity of mitochondria. alpha-Tocopherolquinone has also displayed antioxidant activities after it is reduced to tocopherylhydroquinone.

alpha-Tocopherolquinone

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Purity: 99.89%

Catalog No. T7050Alias MetareneCas No. 7559-04-8

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$93	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Color:Transparent to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

alpha-Tocopherolquinone AI Summary

alpha-Tocopherolquinone exhibits moderate cytotoxicity against human NCI-H460 cells with an IC50 of 37300.0 nM and lower cytotoxicity against MCF7 and SF268 cells with IC50 values greater than 50000.0 nM. It shows cytoprotective activity against BSO-induced human FRDA primary patient fibroblasts with an EC50 of 36.0 nM and a high therapeutic index of >= 8333.0. The low GI50 value of >= 300000.0 nM indicates notable growth inhibition. In pharmacokinetics, it demonstrates moderate to high Cmax values in mouse, rat, and dog plasma, reasonable Tmax values, variable AUC values, and a long half-life in dog plasma. It is orally bioavailable in mice, with moderate clearance and volume of distribution. The solubility of the compound is 10000.0 nM. Additionally, alpha-Tocopherolquinone displays antimycobacterial activity against Mycobacterium tuberculosis H37Rv with a MIC of 25.0 µg/mL. In enzyme inhibition assays, alpha-Tocopherolquinone inhibits TC-PTP with an IC50 of 35,090.0 nM and PTP1B with an IC50 of 3,850.0 nM, but shows less than 50.0% inhibition on SHP1, SHP2, and LAR. It also inhibits CDC25B with an IC50 of 23,230.0 nM. The compound demonstrates cytotoxicity against human HL60 cells (IC50 of 45,000.0 nM) and A549 cells (IC50 of 85,300.0 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	During hypoxia in rats, levels of α-tocopherylquinon have been found to rise. alpha-Tocopherolquinone (Metarene) is reported to downregulate the respiratory activity of mitochondria. alpha-Tocopherolquinone has also displayed antioxidant activities after it is reduced to tocopherylhydroquinone.
Synonyms	Metarene

Chemical Properties

Molecular Weight	446.71
Formula	C₂₉H₅₀O₃
Cas No.	7559-04-8
Smiles	CC(C)CCCC(C)CCCC(C)CCCC(C)(O)CCC1=C(C)C(=O)C(C)=C(C)C1=O
Relative Density.	1.0115 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (111.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2386 mL	11.1929 mL	22.3859 mL	111.9294 mL
5 mM	0.4477 mL	2.2386 mL	4.4772 mL	22.3859 mL
10 mM	0.2239 mL	1.1193 mL	2.2386 mL	11.1929 mL
20 mM	0.1119 mL	0.5596 mL	1.1193 mL	5.5965 mL
50 mM	0.0448 mL	0.2239 mL	0.4477 mL	2.2386 mL
100 mM	0.0224 mL	0.1119 mL	0.2239 mL	1.1193 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc