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Indusatumab vedotin
(Synonyms: TAK-264, MLN0264) Copy Product Info
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Synonyms: TAK-264, MLN0264
Catalog No. T9901A-023 Copy Product Info
Purity: 95%
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Indusatumab vedotin is an antibody-drug conjugate (ADC) consisting of an antibody targeting human guanylate cyclase C (GCC) conjugated with the microtubule inhibitor monomethyl auristatin. It can inhibit the proliferation of pancreatic cancer cells, arrest the cell cycle at G2/M phase, and induce apoptosis.
Indusatumab vedotin
Cas No. 1514889-12-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $758 | - | In Stock | |
| 5 mg | $2,350 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95%
Appearance:Liquid
Color:Transparent
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Product Introduction
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| Description | Indusatumab vedotin is an antibody-drug conjugate (ADC) consisting of an antibody targeting human guanylate cyclase C (GCC) conjugated with the microtubule inhibitor monomethyl auristatin. It can inhibit the proliferation of pancreatic cancer cells, arrest the cell cycle at G2/M phase, and induce apoptosis. |
| In vitro | Indusatumab vedotin exerts significant anti-proliferative effects on pancreatic cancer cell lines when treated at 0.4–25 μg/mL for 72 h.Treatment of MIA PaCa-2 and PANC-1 cells with 12.5 μg/mL for 24 h induces cell cycle arrest at G2/M phase and promotes the expression of phosphorylated histone H3 (P-Histone H3) [1]. |
| In vivo | Indusatumab vedotin administered intravenously at 10 mg/kg once weekly for at least 17 consecutive days significantly inhibits tumor growth rate [1].Indusatumab vedotin demonstrates biological effects highly correlated with drug exposure in mice bearing one of six xenograft tumor models [2]. |
| Synonyms | TAK-264, MLN0264 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal, ADC |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | MMAE |
| Gene ID | |
| Uniprot ID | |
| Target | GUCY2C |
| Cas No. | 1514889-12-3 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Indusatumab vedotin in vivo | Indusatumab vedotin in vitro
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