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Tetradecylthioacetic acid

Catalog No. T9808 CAS 2921-20-2

Tetradecylthioacetic acid is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including activation of peroxisome proliferator activated receptors (PPARs) with preference for PPARα.

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Tetradecylthioacetic acid Chemical Structure

Tetradecylthioacetic acid, CAS 2921-20-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 113.00
50 mg	In stock	$ 178.00
100 mg	In stock	$ 278.00
200 mg	In stock	$ 418.00
500 mg	In stock	$ 682.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Mice receiving HFD supplemented with 0.75% (w/w) TTA had significantly lower body weights compared to mice fed the diet without TTA. Plasma triacylglycerol (TAG) was reduced 3-fold with TTA treatment, concurrent with increase in liver TAG. Total cholesterol was unchanged in plasma and liver. However, TTA promoted a shift in the plasma lipoprotein fractions with an increase in larger HDL particles. Histological analysis of the small intestine revealed a reduced size of lipid droplets in enterocytes of TTA treated mice, accompanied by increased mRNA expression of fatty acid transporter genes. Expression of the cholesterol efflux pump Abca1 was induced in the small intestine, but not in the liver. Scd1 displayed markedly increased mRNA and protein expression in the intestine of the TTA group[1].

Molecular Weight	288.49
Formula	C16H32O2S
CAS No.	2921-20-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (207.98 mM), Sonication is recommended.

References and Literature

1. Lundåsen T, et al. The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL. PLoS One. 2020 Mar 16;15(3):e0229322.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library DNA Damage & Repair Compound Library Anti-Breast Cancer Compound Library Bioactive Compounds Library Max ReFRAME Related Library Nuclear Receptor Compound Library Clinical Compound Library Transcription Factor-Targeted Compound Library

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Keywords

Tetradecylthioacetic acid 2921-20-2 DNA Damage/DNA Repair Metabolism PPAR Peroxisome proliferator-activated receptors β-Oxidation inhibit fatty acid oxidation Inhibitor 2-(Tetradecylthio)acetic acid hypolipidemia inhibitor

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