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Carboxin

Name: Carboxin
Brand: TargetMol
SKU: T5559
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5559Cas No. 5234-68-4

Alias Vitavax, Kisvax, Carboxine, Carbathiin

Carboxin (Kisvax) appears as off-white crystals. Systemic fungicide and seed protectant.

Carboxin

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Purity: 99.52%

Catalog No. T5559Alias Vitavax, Kisvax, Carboxine, CarbathiinCas No. 5234-68-4

Carboxin (Kisvax) appears as off-white crystals. Systemic fungicide and seed protectant.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$31	In Stock	In Stock
100 mg	$41	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.52%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Carboxin AI Summary

Carboxin exhibits a variety of bioactivities across different biological systems and organisms. It shows potency in modulating miRNAs, lipid storage in Drosophila cells, inhibiting the ERK signaling pathway, HADH2, and miR-21, as well as inhibiting Nrf2, histone lysine methyltransferase G9a, HP1-beta chromodomain interactions, peroxisome proliferator-activated receptor delta signaling, DNA re-replication in colon adenocarcinoma cells, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). The compound also activates the human pregnane X receptor (PXR) and antioxidant response element (ARE) signaling pathways and serves as an agonist for cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1), Aryl hydrocarbon Receptor (AhR) signaling pathway, and rat pregnane X receptor (rPXR) signaling pathway. Additionally, it has demonstrated delayed death inhibition of the malarial parasite and activity against firefly luciferase. Carboxin shows significant antiviral activity against SARS-CoV-2 with an IC50 value greater than 20000.0 nM, exhibiting moderate potency. It also possesses antifungal activity against Fusarium graminearum and Fusarium oxysporum, with growth inhibition of 56.3% and 23.6%, respectively, at 100 µg/ml. Its antifungal efficacy extends to controlling wheat leaf rust disease caused by Puccinia recondita with 100% efficacy at 50 µg/ml and 43.0% at 20 µg/ml, and fungicidal activity against Oculimacula yallundae with an EC50 value of 2.5 µg/ml. In terms of antiparasitic activity, Carboxin is effective against the Chagas Disease parasite Trypanosoma cruzi with an IC50 value of 22410.0 nM and an IC90 value of 57500.0 nM, showing no cytotoxicity against L-6 rat myoblasts up to 100000.0 nM. Additionally, it exhibits bioactivities related to resistance in sterol 14alpha-demethylation inhibitor-resistant strains of Oculimacula yallundae..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Carboxin (Kisvax) appears as off-white crystals. Systemic fungicide and seed protectant.
Synonyms	Vitavax, Kisvax, Carboxine, Carbathiin

Chemical Properties

Molecular Weight	235.30
Formula	C₁₂H₁₃NO₂S
Cas No.	5234-68-4
Smiles	CC1=C(SCCO1)C(=O)NC1=CC=CC=C1
Relative Density.	1.45

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 47 mg/mL (199.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2499 mL	21.2495 mL	42.4989 mL	212.4947 mL
5 mM	0.8500 mL	4.2499 mL	8.4998 mL	42.4989 mL
10 mM	0.4250 mL	2.1249 mL	4.2499 mL	21.2495 mL
20 mM	0.2125 mL	1.0625 mL	2.1249 mL	10.6247 mL
50 mM	0.0850 mL	0.4250 mL	0.8500 mL	4.2499 mL
100 mM	0.0425 mL	0.2125 mL	0.4250 mL	2.1249 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc