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Raddeanin A

Name: Raddeanin A
Brand: TargetMol
SKU: T3878
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3878Cas No. 89412-79-3

Alias Raddeanin R3, NSC382873, Anemodeanin A

Raddeanin A is a natural triterpenoid saponin from Cyperus japonicus that inhibits histone deacetylase and is also a potent immunogenic cell death inducer with strong anti-angiogenic and anti-tumor activities.

Raddeanin A

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Purity: 99.94%

Catalog No. T3878Alias Raddeanin R3, NSC382873, Anemodeanin ACas No. 89412-79-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$248	In Stock	In Stock
50 mg	$368	In Stock	In Stock
100 mg	$519	In Stock	In Stock
200 mg	$743	-	In Stock
1 mL x 10 mM (in DMSO)	$146	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Raddeanin A is a natural triterpenoid saponin from Cyperus japonicus that inhibits histone deacetylase and is also a potent immunogenic cell death inducer with strong anti-angiogenic and anti-tumor activities.
In vitro	METHODS: Raddeanin A (NSC-382873) (1, 2, 5 μM, 20 hours) treated B16-HMGB1-Gluc and MC38-HMGB1-Gluc cells, and measured HMGB1-Gluc luciferase activity and extracellular ATP levels. RESULTS Raddeanin A induced a significant increase in HMGB1-Gluc activity and ATP release in both B16 and MC38 cells in a dose-dependent manner.[2]
In vivo	METHODS: Raddeanin A (NSC-382873) (1, 2, and 4 mg/kg, intraperitoneally or intratumorally) was used to treat mice bearing a subcutaneous xenograft model of MC38 melanoma cells to investigate the effects of Raddeanin A on the immune control of tumor growth in vivo. RESULTS Raddeanin A caused considerable suppression of tumor size and weight in MC38 tumor-bearing mice; Raddeanin A effectively suppressed tumor growth in mice bearing B16 melanoma; however, intratumoral treatment with Raddeanin A did not significantly alter mouse body weight. [2]
Synonyms	Raddeanin R3, NSC382873, Anemodeanin A

Chemical Properties

Molecular Weight	897.10
Formula	C₄₇H₇₆O₁₆
Cas No.	89412-79-3
Smiles	[H][C@@]1(O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]2([H])O[C@@H]2[C@@H](O)[C@@H](O)CO[C@@]2([H])O[C@H]2CC[C@@]3(C)[C@@]([H])(CC[C@]4(C)[C@]3([H])CC=C3[C@]5([H])CC(C)(C)CC[C@@]5(CC[C@@]43C)C(O)=O)C2(C)C)O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
Relative Density.	1.36 g/cm3

Storage & Solubility Information

Storage

store under nitrogen,store at low temperature,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 82.50 mg/mL (91.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (2.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1147 mL	5.5735 mL	11.1470 mL	55.7351 mL
5 mM	0.2229 mL	1.1147 mL	2.2294 mL	11.1470 mL
10 mM	0.1115 mL	0.5574 mL	1.1147 mL	5.5735 mL
20 mM	0.0557 mL	0.2787 mL	0.5574 mL	2.7868 mL
50 mM	0.0223 mL	0.1115 mL	0.2229 mL	1.1147 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc