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Raddeanin A

Name: Raddeanin A
Brand: TargetMol
SKU: T3878
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T3878Cas No. 89412-79-3

Alias Raddeanin R3, NSC382873, Anemodeanin A

Raddeanin A is a natural triterpenoid saponin from Cyperus japonicus that inhibits histone deacetylase and is also a potent immunogenic cell death inducer with strong anti-angiogenic and anti-tumor activities.

Raddeanin A

🥰Excellent

Purity: 99.94%

Catalog No. T3878Alias Raddeanin R3, NSC382873, Anemodeanin ACas No. 89412-79-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$248	In Stock	In Stock
50 mg	$368	In Stock	In Stock
100 mg	$519	In Stock	In Stock
200 mg	$743	-	In Stock
1 mL x 10 mM (in DMSO)	$146	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.94%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Raddeanin A is a natural triterpenoid saponin from Cyperus japonicus that inhibits histone deacetylase and is also a potent immunogenic cell death inducer with strong anti-angiogenic and anti-tumor activities.
In vitro	METHODS: Raddeanin A (NSC-382873) (1, 2, 5 μM, 20 hours) treated B16-HMGB1-Gluc and MC38-HMGB1-Gluc cells, and measured HMGB1-Gluc luciferase activity and extracellular ATP levels. RESULTS Raddeanin A induced a significant increase in HMGB1-Gluc activity and ATP release in both B16 and MC38 cells in a dose-dependent manner.[2]
In vivo	METHODS: Raddeanin A (NSC-382873) (1, 2, and 4 mg/kg, intraperitoneally or intratumorally) was used to treat mice bearing a subcutaneous xenograft model of MC38 melanoma cells to investigate the effects of Raddeanin A on the immune control of tumor growth in vivo. RESULTS Raddeanin A caused considerable suppression of tumor size and weight in MC38 tumor-bearing mice; Raddeanin A effectively suppressed tumor growth in mice bearing B16 melanoma; however, intratumoral treatment with Raddeanin A did not significantly alter mouse body weight. [2]
Synonyms	Raddeanin R3, NSC382873, Anemodeanin A

Chemical Properties

Molecular Weight	897.1
Formula	C₄₇H₇₆O₁₆
Cas No.	89412-79-3
Smiles	[H][C@@]1(O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]2([H])O[C@@H]2[C@@H](O)[C@@H](O)CO[C@@]2([H])O[C@H]2CC[C@@]3(C)[C@@]([H])(CC[C@]4(C)[C@]3([H])CC=C3[C@]5([H])CC(C)(C)CC[C@@]5(CC[C@@]43C)C(O)=O)C2(C)C)O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
Relative Density.	1.36 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store under nitrogen,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (55.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1147 mL	5.5735 mL	11.1470 mL	55.7351 mL
5 mM	0.2229 mL	1.1147 mL	2.2294 mL	11.1470 mL
10 mM	0.1115 mL	0.5574 mL	1.1147 mL	5.5735 mL
20 mM	0.0557 mL	0.2787 mL	0.5574 mL	2.7868 mL
50 mM	0.0223 mL	0.1115 mL	0.2229 mL	1.1147 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc