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DQP 1105

Name: DQP 1105
Brand: TargetMol
SKU: T22748
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22748Cas No. 380560-89-4

DQP 1105 is a NMDA receptor antagonist.

DQP 1105

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Purity: 98.6%

Catalog No. T22748Cas No. 380560-89-4

DQP 1105 is a NMDA receptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$88	In Stock	In Stock
25 mg	$188	In Stock	In Stock
50 mg	$266	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.6%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

DQP 1105 AI Summary

DQP 1105 exhibits a high degree of selectivity and activity towards various receptors and biological targets. Notably, it has a selectivity ratio of IC50 for the recombinant GluN2A/GluN2D receptor to IC50 for the GluN2C/GluN2D receptor that is equal to or greater than 50.0, signifying a significant preference for GluN2A/GluN2D over GluN2C/GluN2D receptors. It also demonstrates selective activity towards the NMDA GluN2B receptor over the GluN2D receptor, with a selectivity ratio of IC50 of 41.0, and shows inhibitory activity against the GluN2D receptor with an IC50 value of 2700.0 nM. Additionally, it serves as a negative allosteric modulator of GluN2D, GluN2C, and GluN2B receptors in xenopus laevis oocytes, with respective IC50 values of 2700.0 nM, 7000.0 nM, and 113000.0 nM. Furthermore, DQP 1105 exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 µM, achieving an inhibition rate of 1.71%. It also demonstrates inhibition of the SARS-CoV-2 3CL-Pro protease by 23.82% at a concentration of 20 µM in a FRET-based assay. However, its antiviral activity against SARS-CoV-2 in VERO-6 cells is minimal, with a very low inhibition rate (-0.1%). In addition, DQP 1105 shows significant inhibition (72.5%) of human HDAC6 enzyme activity in an enzymatic assay with a commercial peptide substrate, but only minimal inhibition (0.13%) was observed with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

DQP 1105 is a NMDA receptor antagonist.

Chemical Properties

Molecular Weight	558.42
Formula	C₂₉H₂₄BrN₃O₄
Cas No.	380560-89-4
Smiles	Cc1ccc2[nH]c(=O)c(C3=NN(C(C3)c3ccc(Br)cc3)C(=O)CCC(O)=O)c(-c3ccccc3)c2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (107.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7908 mL	8.9538 mL	17.9077 mL	89.5383 mL
5 mM	0.3582 mL	1.7908 mL	3.5815 mL	17.9077 mL
10 mM	0.1791 mL	0.8954 mL	1.7908 mL	8.9538 mL
20 mM	0.0895 mL	0.4477 mL	0.8954 mL	4.4769 mL
50 mM	0.0358 mL	0.1791 mL	0.3582 mL	1.7908 mL
100 mM	0.0179 mL	0.0895 mL	0.1791 mL	0.8954 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc