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Telisotuzumab vedotin
(Synonyms: ABT399, ABT 399, ABBV-399, ABBV399) Copy Product Info
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Synonyms: ABT399, ABT 399, ABBV-399, ABBV399
Catalog No. T77838 Copy Product Info
Purity: 95%
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Telisotuzumab vedotin (ABBV-399) is an ADC compound targeting c-Met with antitumor activity, used for research in recurrent squamous cell lung cancer.
Telisotuzumab vedotin
Cas No. 1714088-51-3
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $239 | - | In Stock | |
| 5 mg | $591 | - | In Stock | |
| 10 mg | $977 | - | In Stock | |
| 25 mg | $1,450 | - | In Stock | |
| 50 mg | $1,950 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.5% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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Chemical Properties
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| Description | Telisotuzumab vedotin (ABBV-399) is an ADC compound targeting c-Met with antitumor activity, used for research in recurrent squamous cell lung cancer. |
| Targets & IC50 | c-Met:0.30 nmol/L (EC50) |
| In vitro | Telisotuzumab vedotin inhibits the proliferation of cancer cells that overexpress c-Met, These included MET-amplified SNU-620, SNU-5, and Hs 746T gastric cancer cells, as well as c-Met overexpressed NCI-H441, EBC-1, and NCI-H820 NSCLC cell lines. [2] |
| In vivo | Telisotuzumab vedotin (1 or 3 mg/kg, once every 4 days, intrperitoneally administered) inhibits the growth of c-Met inhibitor-resistant xenograft tumors. [2] |
| Synonyms | ABT399, ABT 399, ABBV-399, ABBV399 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | MMAE |
| Gene ID | |
| Uniprot ID | |
| Target | HGFR/c-Met |
| Molecular Weight | 151.37 kDa |
| Cas No. | 1714088-51-3 |
| Isotype | IgG1-MMAE |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 80.00 mg/mL, Sonication is recommended. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Telisotuzumab vedotin in vivo | Telisotuzumab vedotin in vitro | Telisotuzumab vedotin molecular weight
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