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GSK2556286

Catalog No. T9830 CAS 1210456-20-4

Synonyms: GSK286

GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis).GSK2556286 inhibits the growth of human macrophages with an IC50 value of 0.07 μM.GSK2556286 is effective against both multidrug-resistant (MDR) or extensively drug-resistant (XDR) and drug-sensitive (DS) M. tuberculosis. GSK2556286 is effective against multi-drug resistant (MDR) or extensively drug resistant (XDR) and drug sensitive (DS) Mycobacterium tuberculosis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GSK2556286, CAS 1210456-20-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 131.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 563.00
25 mg	In stock	$ 887.00
50 mg	In stock	$ 1,230.00
100 mg	In stock	$ 1,670.00
500 mg	In stock	$ 3,330.00

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Purity: 100%

Purity: 97.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

Macrophages (human):0.07 μM

Synonyms	GSK286
Molecular Weight	329.39
Formula	C18H23N3O3
CAS No.	1210456-20-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.0 mg/mL (9.1 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Nuermberger EL, et al. GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment. Antimicrob Agents Chemother. 2022;66(6):e0013222. 2. Brown KL, et al. Cyclic AMP-Mediated Inhibition of Cholesterol Catabolism in Mycobacterium tuberculosis by the Novel Drug Candidate GSK2556286. Antimicrob Agents Chemother. 2023;67(1):e0129422.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Bioactive Compounds Library Max Bioactive Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

Cyclo(L-Pro-L-Val) Ethyl acetoacetate Taniborbactam Murepavadin acetate(944252-63-5 free base) Mevastatin Etzadroxil Sitafloxacin Hydrate 4,5-Dimethoxycanthin-6-one

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK2556286 1210456-20-4 Microbiology/Virology Antibacterial GSK 286 GSK 2556286 GSK-286 GSK286 GSK-2556286 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.