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Sotuletinib hydrochloride

Name: Sotuletinib hydrochloride
Brand: TargetMol
SKU: T72211
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72211Cas No. 2222138-31-8

Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM), exhibiting 1000-fold greater selectivity than other receptor tyrosine kinase homologues. It elevates liver enzymes and induces Kupffer cell depletion, making it suitable for studying amyotrophic lateral sclerosis (ALS) and metastatic triple-negative breast cancer (TNBC).

Sotuletinib hydrochloride

🥰Excellent

Purity: 98.812%

Catalog No. T72211Cas No. 2222138-31-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	-	In Stock
5 mg	$73	-	In Stock
10 mg	$113	-	In Stock
25 mg	$172	-	In Stock
50 mg	$228	-	In Stock
100 mg	$396	-	In Stock
200 mg	$578	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.812%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM), exhibiting 1000-fold greater selectivity than other receptor tyrosine kinase homologues. It elevates liver enzymes and induces Kupffer cell depletion, making it suitable for studying amyotrophic lateral sclerosis (ALS) and metastatic triple-negative breast cancer (TNBC).
Targets&IC50	CSF1R (FMS):1 nM
In vitro	Methods: Bone marrow-derived macrophages (BMDMs) were treated with Sotuletinib hydrochloride (67nM-6700nM), and cell proliferation was assessed via MTT assay. Results: Sotuletinib hydrochloride significantly inhibited CSF-1-dependent proliferation and CSF-1R phosphorylation in BMDMs.[1]
In vivo	Methods: Sotuletinib hydrochloride (200 mg/kg, once daily) was administered to MMTV-PyMT mice via oral gavage to assess the effects of Sotuletinib hydrochloride on tumor growth, TAMs, and CD8+ T cells. Results: Sotuletinib hydrochloride treatment significantly decreased TAMs and tumor volume while enhancing the infiltration of CD8+ T cells.[2]

Chemical Properties

Molecular Weight	434.94
Formula	C₂₀H₂₃ClN₄O₃S
Cas No.	2222138-31-8
Smiles	N(C=1SC=2C(N1)=CC=C(OC=3C=C(C(NC)=O)N=CC3)C2)[C@H]4[C@H](O)CCCC4.Cl
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (183.93 mM), Sonication is recommended.

H2O: 80.00 mg/mL (183.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2992 mL	11.4958 mL	22.9917 mL	114.9584 mL
5 mM	0.4598 mL	2.2992 mL	4.5983 mL	22.9917 mL
10 mM	0.2299 mL	1.1496 mL	2.2992 mL	11.4958 mL
20 mM	0.1150 mL	0.5748 mL	1.1496 mL	5.7479 mL
50 mM	0.0460 mL	0.2299 mL	0.4598 mL	2.2992 mL
100 mM	0.0230 mL	0.1150 mL	0.2299 mL	1.1496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc