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Sotuletinib hydrochloride
🥰Excellent
Catalog No. T72211Cas No. 2222138-31-8
Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM), exhibiting 1000-fold greater selectivity than other receptor tyrosine kinase homologues. It elevates liver enzymes and induces Kupffer cell depletion, making it suitable for studying amyotrophic lateral sclerosis (ALS) and metastatic triple-negative breast cancer (TNBC).
Sotuletinib hydrochloride
🥰Excellent
Purity: 98.812%
Catalog No. T72211Cas No. 2222138-31-8
Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM), exhibiting 1000-fold greater selectivity than other receptor tyrosine kinase homologues. It elevates liver enzymes and induces Kupffer cell depletion, making it suitable for studying amyotrophic lateral sclerosis (ALS) and metastatic triple-negative breast cancer (TNBC).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock | |
| 5 mg | $73 | In Stock | |
| 10 mg | $113 | In Stock | |
| 25 mg | $172 | In Stock | |
| 50 mg | $228 | In Stock | |
| 100 mg | $396 | In Stock | |
| 200 mg | $578 | In Stock |
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Purity:98.812%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM), exhibiting 1000-fold greater selectivity than other receptor tyrosine kinase homologues. It elevates liver enzymes and induces Kupffer cell depletion, making it suitable for studying amyotrophic lateral sclerosis (ALS) and metastatic triple-negative breast cancer (TNBC). |
| Targets&IC50 | CSF1R (FMS):1 nM |
| In vitro | Methods: Bone marrow-derived macrophages (BMDMs) were treated with Sotuletinib hydrochloride (67nM-6700nM), and cell proliferation was assessed via MTT assay. Results: Sotuletinib hydrochloride significantly inhibited CSF-1-dependent proliferation and CSF-1R phosphorylation in BMDMs.[1] |
| In vivo | Methods: Sotuletinib hydrochloride (200 mg/kg, once daily) was administered to MMTV-PyMT mice via oral gavage to assess the effects of Sotuletinib hydrochloride on tumor growth, TAMs, and CD8+ T cells. Results: Sotuletinib hydrochloride treatment significantly decreased TAMs and tumor volume while enhancing the infiltration of CD8+ T cells.[2] |
| Molecular Weight | 434.94 |
| Formula | C20H23ClN4O3S |
| Cas No. | 2222138-31-8 |
| Smiles | N(C=1SC=2C(N1)=CC=C(OC=3C=C(C(NC)=O)N=CC3)C2)[C@H]4[C@H](O)CCCC4.Cl |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (183.93 mM), Sonication is recommended. H2O: 80.00 mg/mL (183.93 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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