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FGF-19 Protein, Human, Recombinant
(Synonyms: fibroblast growth factor 19, FGF19) Copy Product InfoSynonyms: fibroblast growth factor 19, FGF19
Catalog No. TMPY-02907 Copy Product Info
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. It interacts with KL and KLB directly. However, it interacts with FGFR4 in the presence of heparin, KL or KLB. FGF19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. It also stimulates glucose uptake in adipocytes.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $98 | - | In Stock | |
| 10 μg | $165 | - | In Stock | |
| 20 μg | $273 | - | In Stock | |
| 50 μg | $543 | - | In Stock | |
| 100 μg | $949 | 7-10 days | 7-10 days | |
| 200 μg | $1,670 | 7-10 days | 7-10 days | |
| 500 μg | $3,530 | 7-10 days | 7-10 days | |
| 1 mg | $6,230 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:SDS-PAGE: 97.4%; SEC-HPLC: 99.5%
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. It interacts with KL and KLB directly. However, it interacts with FGFR4 in the presence of heparin, KL or KLB. FGF19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. It also stimulates glucose uptake in adipocytes. |
| Species | Human |
| Expression System | E. coli |
| Tag | Tag Free |
| Accession Number | O95750-1 |
| Construction | A DNA sequence encoding the mature form of human FGF19 (O95750-1) (Phe27-Lys216) was expressed with a N-terminal Met. Predicted N terminal: Met |
| Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. https://cdn.targetmol.com/group3/M00/3E/E1/CgoaEGbEi26EPJfpAAAAANj6tf4906.png,https://cdn.targetmol.com/group3/M00/3E/E1/CgoaEGbEi26EcjHdAAAAAALdtuE526.png |
| Endotoxin | < 10 EU/mg of the protein. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | fibroblast growth factor 19, FGF19 |
| Research Background |
| Molecular Weight | 21.4 kDa (predicted); 23 kDa (reducing conditions) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: FGF-19 Protein, Human, Recombinant chemical structure | FGF-19 Protein, Human, Recombinant molecular weight
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