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MP07-66

Name: MP07-66
Brand: TargetMol
SKU: T9744
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9744Cas No. 1938056-90-6

MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.

MP07-66

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Purity: 95.67%

Catalog No. T9744Cas No. 1938056-90-6

MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	-	In Stock
5 mg	$59	-	In Stock
10 mg	$95	-	In Stock
25 mg	$172	-	In Stock
50 mg	$250	-	In Stock
100 mg	$345	-	In Stock
1 mL x 10 mM (in DMSO)	$64	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:95.67%

Appearance:Liquid

Color:Transparent

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.

In vitro

CLL cells were incubated with increasing concentrations of MP07-66 (0-16 μM) for 24 and 48 hours and then subject to annexin V–PI flow cytometry. The level of apoptosis reached 50% and 80%, at 24 hours and 48 hours, respectively, at a MP07-66 concentration as high as 16 μM, which paralleled PARP cleavage, a marker of caspase-dependent apoptosis. In addition, the phosphorylation status of PP2A targets, namely Akt, GSK-3, and SHP-1, was negatively affected by the treatment with MP07-66, triggering known downstream events promoting apoptosis, such as Mcl-1 degradation and caspase-3 activation[1].

Chemical Properties

Molecular Weight	323.47
Formula	C₁₉H₃₃NO₃
Cas No.	1938056-90-6
Smiles	CCCCCCOc1ccc(CNCC(OCC)OCC)cc1
Relative Density.	0.970 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (772.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0915 mL	15.4574 mL	30.9148 mL	154.5738 mL
5 mM	0.6183 mL	3.0915 mL	6.1830 mL	30.9148 mL
10 mM	0.3091 mL	1.5457 mL	3.0915 mL	15.4574 mL
20 mM	0.1546 mL	0.7729 mL	1.5457 mL	7.7287 mL
50 mM	0.0618 mL	0.3091 mL	0.6183 mL	3.0915 mL
100 mM	0.0309 mL	0.1546 mL	0.3091 mL	1.5457 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc