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(-)-Huperzine A

Name: (-)-Huperzine A
Brand: TargetMol
SKU: T3026
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3026Cas No. 102518-79-6

Alias Huperzine A, HupA

(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).

(-)-Huperzine A

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Purity: 99.46%

Catalog No. T3026Alias Huperzine A, HupACas No. 102518-79-6

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$43	In Stock	In Stock
25 mg	$82	In Stock	In Stock
50 mg	$148	In Stock	In Stock
100 mg	$263	In Stock	In Stock
200 mg	$490	-	In Stock
500 mg	$785	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.46%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
Targets&IC50	AChE (G4 form):7 nM(Ki)
In vitro	In both animal models and patients with Alzheimer's Disease (AD), (-)-Huperzine A has been shown to improve learning and memory impairments. Compared to the control group treated with saline, significant inhibition of acetylcholinesterase (AchE) activity was observed in the cortex, striatum, hippocampus, medulla, septal nuclei, cerebellum, and thalamus of rats 30 minutes post-mortem.
In vivo	Compared to tacrine, strychnine, galantamine, and carbachol, (-)-Huperzine A exhibits stronger inhibition of acetylcholinesterase (AChE) activity but has the least effect on butyrylcholinesterase (BuChE). (-)-Huperzine A protects cells against glutamate, hydrogen peroxide, β-amyloid, ischemia, and astrosporine-induced cytotoxicity and apoptosis. This protective function is achieved through a series of processes including the regulation of apoptotic protein expression (such as Bcl-2, Bax, p53, and caspase-3), alleviation of oxidative stress, mitochondrial protection, upregulation of nerve growth factor and its receptors, and interference with amyloid precursor protein metabolism. Notably, (-)-Huperzine A preferentially inhibits the tetrameric form of AChE (G4 form).
Synonyms	Huperzine A, HupA

Chemical Properties

Molecular Weight	242.32
Formula	C₁₅H₁₈N₂O
Cas No.	102518-79-6
Smiles	[H][C@@]12Cc3[nH]c(=O)ccc3[C@@](N)(CC(C)=C1)C2=CC
Relative Density.	1.20 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1031.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (20.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1268 mL	20.6339 mL	41.2677 mL	206.3387 mL
5 mM	0.8254 mL	4.1268 mL	8.2535 mL	41.2677 mL
10 mM	0.4127 mL	2.0634 mL	4.1268 mL	20.6339 mL
20 mM	0.2063 mL	1.0317 mL	2.0634 mL	10.3169 mL
50 mM	0.0825 mL	0.4127 mL	0.8254 mL	4.1268 mL
100 mM	0.0413 mL	0.2063 mL	0.4127 mL	2.0634 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc