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TargetMol | Compound Library

High-Efficiency Gene Editing Small Molecule Library

Catalog No. L3910

In modern biomedical research, CRISPR-Cas technology has emerged as a mainstream tool for gene editing. Its high efficiency and programmability have enabled broad applications in gene therapy, crop improvement, functional genomics, and disease model development. However, several key challenges remain in practical applications of the CRISPR-Cas system, including off-target effects and limited editing efficiency. In particular, the low efficiency of homology-directed repair (HDR) in mammalian cells significantly hampers the implementation of precise gene edits, such as point mutations or gene knock-ins.
To address these limitations, researchers have been actively developing auxiliary tools to enhance the performance of the CRISPR-Cas system. This library includes a wide range of known DNA repair pathway modulators and potential regulatory molecules, particularly small molecules that inhibit the non-homologous end joining (NHEJ) pathway or promote the HDR pathway. Representative compounds include DNA-PK inhibitors, DNA ligase IV inhibitors, and RAD51 activators. The library features a diverse collection of synthetic compounds, natural products, and approved/clinical drugs, offering broad potential for application across various research and therapeutic contexts.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L3910

High-Efficiency Gene Editing Small Molecule Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • Offers 910 small molecules that enhance gene editing efficiency, suitable for high- throughput screening (HTS) and high- content screening (HCS);
  • The targets include DNA- PK、DNA ligase IV、RAD51 and others;
  • Structurally diverse, medicinally active, and cell permeable;
  • Rich documentation with structure, target, IC50 value and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

CDK
Apoptosis
Histone Methyltransferase
HDAC
Microtubule Associated
PARP
Autophagy
Sirtuin
DNA-PK
ATM/ATR
PI3K
GSK-3
DNA Methyltransferase
Epigenetic Reader Domain
mTOR
Wnt/beta-catenin
Caspase
Parasite
Aurora Kinase
HIV Protease
FLT
Src
VEGFR
Bcl-2 Family
ERK
Endogenous Metabolite
JAK
PROTACs
Akt
Casein Kinase
Chk
CRISPR/Cas9
DNA/RNA Synthesis
DYRK
Mitophagy
PKA
PKC
Antibiotic
Bcr-Abl
NF-κB
p53
Ras
S6 Kinase
Virus Protease
AChR
Antibacterial
Gamma-secretase
Histone Demethylase
p38 MAPK
ADC Cytotoxin
Adrenergic Receptor
COX
Cytochromes P450
Dehydrogenase
EGFR
FGFR
GABA Receptor
Histone Acetyltransferase
HSV
Influenza Virus
MAPK
Nrf2
PDE
Pim
Reactive Oxygen Species
Serine/threonin kinase
SGK
Topoisomerase
AMPK
Beta Amyloid
Cholecystokinin Receptor
c-RET
DNA Alkylation
FAK
HIF
Histamine Receptor
IL Receptor
IκB/IKK
LRRK2
MEK
NO Synthase
Phosphatase
PPAR
PYK2
STAT
Trk receptor
Tyrosine Kinases
5-HT Receptor
Adenosine Receptor
Antifungal
Antioxidant
Antiviral
Calcium Channel
Carbonic Anhydrase
c-Fms
c-Met/HGFR
DUB
IRAK
Kinesin
Lipoxygenase
Molecular Glues
Nucleoside Antimetabolite/Analog
PDGFR
PDK
PI4K
PLK
Raf
Reverse Transcriptase
ROCK
SARS-CoV
Sodium Channel
TNF
Tyrosinase
ALK
Antifection
Antifolate
Anti-infection
Aryl Hydrocarbon Receptor
ATPase
BACE
Carboxypeptidase
CCR
Cholinesterase (ChE)
c-Kit
c-Myc
DAPK
Estrogen/progestogen Receptor
Ferroptosis
Free radical scavengers
Haspin Kinase
HBV
HCV Protease
HER
HIF/HIF Prolyl-Hydroxylase
IAP
IGF-1R
Immunology/Inflammation related
Interleukin
JNK
LIM Kinase
Mdm2
MELK
MLK
MMP
NADPH
NMDAR
NOD
NOS
PAD
PAFR
PERK
P-gp
Phospholipase
Proteasome
RAAS
Rho
RIP kinase
Serine Protease
Syk
Telomerase
TOPK
Transferase
UGT