Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
TargetMol | Compound Library

High-Efficiency Gene Editing Small Molecule Library

Catalog No. L3910

In modern biomedical research, CRISPR-Cas technology has emerged as a mainstream tool for gene editing. Its high efficiency and programmability have enabled broad applications in gene therapy, crop improvement, functional genomics, and disease model development. However, several key challenges remain in practical applications of the CRISPR-Cas system, including off-target effects and limited editing efficiency. In particular, the low efficiency of homology-directed repair (HDR) in mammalian cells significantly hampers the implementation of precise gene edits, such as point mutations or gene knock-ins.
To address these limitations, researchers have been actively developing auxiliary tools to enhance the performance of the CRISPR-Cas system. This library includes a wide range of known DNA repair pathway modulators and potential regulatory molecules, particularly small molecules that inhibit the non-homologous end joining (NHEJ) pathway or promote the HDR pathway. Representative compounds include DNA-PK inhibitors, DNA ligase IV inhibitors, and RAD51 activators. The library features a diverse collection of synthetic compounds, natural products, and approved/clinical drugs, offering broad potential for application across various research and therapeutic contexts.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Resource Download
Library compound info
Excel
SDF
Contact us for more batch information

Catalog No. L3910

High-Efficiency Gene Editing Small Molecule Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
Inquiry & Custom

Top Publication Citing
Use of TargetMol Products

Cite scientific literature on TargetMol products

View More

Product Description Product Description

  • Offers 910 small molecules that enhance gene editing efficiency, suitable for high- throughput screening (HTS) and high- content screening (HCS);
  • The targets include DNA- PK、DNA ligase IV、RAD51 and others;
  • Structurally diverse, medicinally active, and cell permeable;
  • Rich documentation with structure, target, IC50 value and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
Inquiry & Custom

Sci Citations

Library Customization | TargetMol Library Composition

CDK
Apoptosis
Histone Methyltransferase
HDAC
Microtubule Associated
PARP
Autophagy
Sirtuin
DNA-PK
ATM/ATR
PI3K
GSK-3
DNA Methyltransferase
Epigenetic Reader Domain
mTOR
Caspase
Antibacterial
Endogenous Metabolite
Ras
HIV Protease
Wnt/beta-catenin
Parasite
Bcl-2 Family
ERK
VEGFR
Aurora Kinase
FLT
Src
Virus Protease
JAK
PROTACs
DYRK
Mitophagy
PKC
DNA/RNA Synthesis
MAPK
CRISPR/Cas9
Antibiotic
PKA
Reactive Oxygen Species
Chk
Akt
Casein Kinase
NF-κB
p38 MAPK
MDM-2/p53
Histone Demethylase
Bcr-Abl
Gamma-secretase
S6 Kinase
p53
Serine/threonin kinase
PDE
Molecular Glues
EGFR
Histone Acetyltransferase
Influenza Virus
Beta Amyloid
HIF/HIF Prolyl-Hydroxylase
ADC Cytotoxin
Dehydrogenase
Phosphatase
Tyrosine Kinases
PPAR
Pim
Adrenergic Receptor
Topoisomerase
Arp2/3 Complex
HSV
Cytochromes P450
Nrf2
STAT
GABA Receptor
FGFR
SGK
AChR
Antifungal
Histamine Receptor
c-Myc
Cholecystokinin Receptor
Nucleoside Antimetabolite/Analog
PYK2
Calcium Channel
Aryl Hydrocarbon Receptor
Raf
DNA Alkylation
IL Receptor
COX
Interleukin
SARS-CoV
LRRK2
Trk receptor
IκB/IKK
AMPK
HIF
c-RET
TNF
Anti-infection
FAK
NO Synthase
Carbonic Anhydrase
c-Met/HGFR
Antioxidant
Adenosine Receptor
HBV
Serine Protease
ROCK
NR4A
PDGFR
Angiotensin-converting Enzyme (ACE)
MMP
Lipoxygenase
DUB
OXPHOS
P-gp
Antiviral
Reverse Transcriptase
c-Fms
PI4K
PDK
5-HT Receptor
PLK
MEK
Potassium Channel
Sodium Channel
IRAK
Kinesin
Proteasome
Mdm2
ATPase
NOS
Transferase
HCV Protease
Amino Acids and Derivatives
MyD88
Estrogen/progestogen Receptor
Ligands for Target Protein for PROTAC
Ferroptosis
DNA Alkylator/Crosslinker
BACE
NADPH
RAAS
PERK
JNK
TOPK
Rho
Antifolate
LIM Kinase
IDO
IAP
Immunology/Inflammation related
RIP kinase
UGT
PAFR
Endonuclease
Haspin Kinase
Drug Metabolite
NMDAR
Glucosidase
Antifection
Fatty Acid Synthase
PAK
CCR
Cholinesterase (ChE)
PAD
IGF-1R
Indoleamine 2,3-Dioxygenase (IDO)
Telomerase
TGF-beta/Smad
HSP
TLR
Free radical scavengers
Aminopeptidase
Pyroptosis
ALK
MELK
Methionine Adenosyltransferase (MAT)
Carboxypeptidase
Retinoid Receptor
Phospholipase
DAPK
Syk
c-Kit
NOD
Tyrosinase
CFTR
MLK
HER
Drug-Linker Conjugates for ADC

Keywords