High-Efficiency Gene Editing Small Molecule Library
Catalog No. L3910
In modern biomedical research, CRISPR-Cas technology has emerged as a mainstream tool for gene editing. Its high efficiency and programmability have enabled broad applications in gene therapy, crop improvement, functional genomics, and disease model development. However, several key challenges remain in practical applications of the CRISPR-Cas system, including off-target effects and limited editing efficiency. In particular, the low efficiency of homology-directed repair (HDR) in mammalian cells significantly hampers the implementation of precise gene edits, such as point mutations or gene knock-ins.
To address these limitations, researchers have been actively developing auxiliary tools to enhance the performance of the CRISPR-Cas system. This library includes a wide range of known DNA repair pathway modulators and potential regulatory molecules, particularly small molecules that inhibit the non-homologous end joining (NHEJ) pathway or promote the HDR pathway. Representative compounds include DNA-PK inhibitors, DNA ligase IV inhibitors, and RAD51 activators. The library features a diverse collection of synthetic compounds, natural products, and approved/clinical drugs, offering broad potential for application across various research and therapeutic contexts.
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Resource Download
Library compound info
Excel
SDF
Contact us for more batch information