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Opucolimab

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Catalog No. T77120Cas No. 2251771-79-4
Alias HLX43 antibody, HLX20

Opucolimab represents a highly specialized humanized monoclonal antibody specifically engineered to target the human Claudin 18.2 protein with exceptional binding affinity and selectivity, effectively facilitating the measurable detection and neutralization of target-positive malignant cells across various preclinical experimental models to evaluate the efficacy of antibody-drug conjugates during strictly monitored laboratory observation periods and molecular investigations to ensure experimental accuracy.

Opucolimab

Opucolimab

Copy Product Info
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Catalog No. T77120Alias HLX43 antibody, HLX20Cas No. 2251771-79-4
Opucolimab represents a highly specialized humanized monoclonal antibody specifically engineered to target the human Claudin 18.2 protein with exceptional binding affinity and selectivity, effectively facilitating the measurable detection and neutralization of target-positive malignant cells across various preclinical experimental models to evaluate the efficacy of antibody-drug conjugates during strictly monitored laboratory observation periods and molecular investigations to ensure experimental accuracy.
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5 mgInquiryInquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Opucolimab represents a highly specialized humanized monoclonal antibody specifically engineered to target the human Claudin 18.2 protein with exceptional binding affinity and selectivity, effectively facilitating the measurable detection and neutralization of target-positive malignant cells across various preclinical experimental models to evaluate the efficacy of antibody-drug conjugates during strictly monitored laboratory observation periods and molecular investigations to ensure experimental accuracy.
In vitro
In functional assays using CLDN18.2-expressing gastric cancer cell lines, Opucolimab (as an ADC) induced rapid endocytosis and demonstrated cytotoxic activity with IC50 values of 0.01-0.5 nM [1].
In vivo
In human gastric cancer CDX and PDX mouse models, systemic administration of Opucolimab significantly suppressed tumor growth and induced tumor regression at low doses [1].
SynonymsHLX43 antibody, HLX20
Reactivity
Human
Application
FACS
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Uniprot ID
TargetPD-L1
Chemical Properties
Cas No.2251771-79-4
Antibody Information
IsotypeIgG1
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

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