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Opucolimab (Synonyms: HLX43 antibody, HLX20)

Catalog No. T77120 Copy Product Info
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Opucolimab represents a highly specialized humanized monoclonal antibody specifically engineered to target the human Claudin 18.2 protein with exceptional binding affinity and selectivity, effectively facilitating the measurable detection and neutralization of target-positive malignant cells across various preclinical experimental models to evaluate the efficacy of antibody-drug conjugates during strictly monitored laboratory observation periods and molecular investigations to ensure experimental accuracy.

Opucolimab

Copy Product Info
🥰Excellent
Catalog No. T77120
Synonyms HLX43 antibody, HLX20

Opucolimab represents a highly specialized humanized monoclonal antibody specifically engineered to target the human Claudin 18.2 protein with exceptional binding affinity and selectivity, effectively facilitating the measurable detection and neutralization of target-positive malignant cells across various preclinical experimental models to evaluate the efficacy of antibody-drug conjugates during strictly monitored laboratory observation periods and molecular investigations to ensure experimental accuracy.

Opucolimab
Cas No. 2251771-79-4
Pack SizePriceUSA StockGlobal StockQuantity
5 mgInquiryInquiryInquiry
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Opucolimab represents a highly specialized humanized monoclonal antibody specifically engineered to target the human Claudin 18.2 protein with exceptional binding affinity and selectivity, effectively facilitating the measurable detection and neutralization of target-positive malignant cells across various preclinical experimental models to evaluate the efficacy of antibody-drug conjugates during strictly monitored laboratory observation periods and molecular investigations to ensure experimental accuracy.
In vitro
In functional assays using CLDN18.2-expressing gastric cancer cell lines, Opucolimab (as an ADC) induced rapid endocytosis and demonstrated cytotoxic activity with IC50 values of 0.01-0.5 nM [1].
In vivo
In human gastric cancer CDX and PDX mouse models, systemic administration of Opucolimab significantly suppressed tumor growth and induced tumor regression at low doses [1].
SynonymsHLX43 antibody, HLX20
Reactivity
Human
Application
FACS
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Uniprot ID
TargetPD-L1
Chemical Properties
Cas No.2251771-79-4
Antibody Information
IsotypeIgG1
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

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