Shopping Cart

Your shopping cart is currently empty

Dp44mT

Name: Dp44mT
Brand: TargetMol
SKU: T6821
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6821Cas No. 152095-12-0

Dp44mT, a effective iron chelator, has selective antitumor activity.

Dp44mT

🥰Excellent

Purity: 99.02%

Catalog No. T6821Cas No. 152095-12-0

Dp44mT, a effective iron chelator, has selective antitumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$197	In Stock	In Stock
200 mg	$258	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.02%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Dp44mT, a effective iron chelator, has selective antitumor activity.
In vitro	In MDA-MB-231 cells, Dp44mT selectively targets towards topoisomerase topo2α resulting in DNA damage. Dp44mT inhibits antiproliferative effects significantly with IC50 of 30 nM, 60 nM, and 60 nM for SK-N-MC, SK-Mel-28, and MCF-7 cells, respectively, while showing no effects on normal MRC-5 fibroblasts. In SK-N-MC neuroepithelioma and M109 cells,Dp44mT inhibits cellular Fe uptake from Fe-Tf , and induces cell apoptosis. Dp44mT, as a Pgp substrate, also overcomes multidrug resistance by the hijacking of lysosomal P-glycoprotein (Pgp).
In vivo	Dp44mT (0.4 mg/kg, i.v.) inhibits M109 tumor implanted in CD2F1 mice by a dose-dependent manner.
Cell Research	SK-N-MC, SK-Mel-28, MCF-7 and MRC-5 cells are incubated in the presence and absence of DFO, 311, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, doxorubicin, and the DpT series of chelators (0-25 μM) for 72 hours at 37°C. The effect of the chelators on proliferation is examined using the MTT assay.
Animal Research	CD2F1 mice that are implanted M109 tumors intravenous inject Dp44mT (dissolved in Propylene glycol) 4 mg/kg in twice daily.

Chemical Properties

Molecular Weight	285.37
Formula	C₁₄H₁₅N₅S
Cas No.	152095-12-0
Smiles	CN(C)C(=S)NN=C(c1ccccn1)c1ccccn1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (58.4 mM), Sonication is recommended.

Ethanol: 47 mg/mL (164.7 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.5042 mL	17.5211 mL	35.0422 mL	175.2111 mL
5 mM	0.7008 mL	3.5042 mL	7.0084 mL	35.0422 mL
10 mM	0.3504 mL	1.7521 mL	3.5042 mL	17.5211 mL
20 mM	0.1752 mL	0.8761 mL	1.7521 mL	8.7606 mL
50 mM	0.0701 mL	0.3504 mL	0.7008 mL	3.5042 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0350 mL	0.1752 mL	0.3504 mL	1.7521 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc