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Cefamandole nafate

Name: Cefamandole nafate
Brand: TargetMol
SKU: T4992
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4992Cas No. 42540-40-9

Alias Cephamandole nafate, Cefamandole formate sodium

Cefamandole nafate (Cephamandole nafate) is a second-generation broad-spectrum cephalosporin antibiotic.

Cefamandole nafate

Copy Product Info

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Catalog No. T4992Alias Cephamandole nafate, Cefamandole formate sodiumCas No. 42540-40-9

Cefamandole nafate (Cephamandole nafate) is a second-generation broad-spectrum cephalosporin antibiotic.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	-	In Stock
500 mg	$61	-	In Stock
1 g	$89	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Cefamandole nafate AI Summary

Cefamandole nafate demonstrates multifaceted bioactivity across various biological targets. It inhibits Pseudomonas aeruginosa MurF ATPase activity at 5 µM with 84.0% residual enzyme activity and exhibits an IC50 value greater than 5,000,000 nM. Additionally, it affects liver function markers, increasing levels of alkaline phosphatase, SGOT, SGPT, LDH, and GGT. It also acts as a Glutaminase (GLS) inhibitor with a potency of 22,387.2 nM. The compound inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells with inhibition percentages of 63.0% and 64.97% at 10 µM, respectively. In antiviral assays, it shows minimal inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM, with inhibition percentages of -1.93% and -0.21%, respectively. It also exhibits a low inhibition percentage of 0.5659% against the SARS-CoV-2 3CL-Pro protease at 20 µM. Furthermore, it is a potential inhibitor of human HDAC6, with inhibition percentages of 16.19% using a commercial peptide substrate and 1.33% using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cefamandole nafate (Cephamandole nafate) is a second-generation broad-spectrum cephalosporin antibiotic.
Synonyms	Cephamandole nafate, Cefamandole formate sodium

Chemical Properties

Molecular Weight	512.49
Formula	C₁₉H₁₇N₆NaO₆S₂
Cas No.	42540-40-9
Smiles	[Na+].CN1N=NN=C1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](OC=O)C1=CC=CC=C1)C2=O)C([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 29 mg/mL (56.59 mM), Sonication is recommended.

DMSO: 41 mg/mL (80 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9513 mL	9.7563 mL	19.5126 mL	97.5629 mL
5 mM	0.3903 mL	1.9513 mL	3.9025 mL	19.5126 mL
10 mM	0.1951 mL	0.9756 mL	1.9513 mL	9.7563 mL
20 mM	0.0976 mL	0.4878 mL	0.9756 mL	4.8781 mL
50 mM	0.0390 mL	0.1951 mL	0.3903 mL	1.9513 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc