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L-Arginine hydrochloride
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Catalog No. T0670Cas No. 1119-34-2
Alias L-arginine monohydrochloride, L-Arginine HCl (L-Arg), (S)-(+)-Arginine hydrochloride
L-Arginine hydrochloride serve as substrates and nitrogen donors for endothelial nitric oxide synthase (eNOS) to produce nitric oxide (NO). They are transported into vascular smooth muscle cells via cationic amino acid transporters, where they are metabolized into NO, polyamines, or L-proline. As effective vasodilators, they are commonly used to induce experimental acute pancreatitis models.
L-Arginine hydrochloride
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Purity: 99.51%
Catalog No. T0670Alias L-arginine monohydrochloride, L-Arginine HCl (L-Arg), (S)-(+)-Arginine hydrochlorideCas No. 1119-34-2
L-Arginine hydrochloride serve as substrates and nitrogen donors for endothelial nitric oxide synthase (eNOS) to produce nitric oxide (NO). They are transported into vascular smooth muscle cells via cationic amino acid transporters, where they are metabolized into NO, polyamines, or L-proline. As effective vasodilators, they are commonly used to induce experimental acute pancreatitis models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 g | $33 | In Stock | In Stock | |
| 2 g | $36 | - | In Stock | |
| 5 g | $42 | - | In Stock | |
| 10 g | $59 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.51%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | L-Arginine hydrochloride serve as substrates and nitrogen donors for endothelial nitric oxide synthase (eNOS) to produce nitric oxide (NO). They are transported into vascular smooth muscle cells via cationic amino acid transporters, where they are metabolized into NO, polyamines, or L-proline. As effective vasodilators, they are commonly used to induce experimental acute pancreatitis models. |
| In vitro | In individuals with sickle cell anemia, oral administration of L-Arginine (0.1 g/kg) significantly reduces pulmonary arterial systolic pressure after 5 days. Continuous treatment with L-Arginine (4 mg/kg per minute for 1 hour) in rabbit limbs subjected to regional ischemia/reperfusion reduced superoxide production by cNOS, thereby increasing NO accumulation. In SV-129 mice, subcutaneous injection of L-Arginine (2 mg/kg) resulted in the upregulation of eNOS. |
| In vivo | Treatment with L-Arginine (0.3 mM) for 30 minutes significantly increases nitric oxide (NO) production in bovine aortic endothelial cells exposed to n-LDL and oxidized-LDL. |
| Synonyms | L-arginine monohydrochloride, L-Arginine HCl (L-Arg), (S)-(+)-Arginine hydrochloride |
| Molecular Weight | 210.66 |
| Formula | C6H15ClN4O2 |
| Cas No. | 1119-34-2 |
| Smiles | C(=O)([C@@H](N)CCCNC(=N)N)O.Cl |
| Relative Density. | 1.42 g/cm3. Temperature:20 °C. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 10 mM, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
NOSynthaseNOSNO SynthaseNitric oxide synthasesL-arginine MonohydrochlorideL-Arginine HydrochlorideLArginine hydrochlorideL-Arginine HClL-ArginineL-ArgL Arginine hydrochlorideInhibitorinhibitEndogenousMetaboliteEndogenous MetaboliteArginine HydrochlorideAminoAcidsandDerivativesAmino Acids and Derivatives
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