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Cytidine 5'-monophosphate

Name: Cytidine 5'-monophosphate
Brand: TargetMol
SKU: TMO2752
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TMO2752Cas No. 63-37-6

Alias Cytidylic Acid, 5'-Cytidylic acid, 5'-CMP

Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide integral to RNA, comprising the nucleobase cytosine, pentose ribose, and phosphate groups.

Cytidine 5'-monophosphate

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Purity: 99.10%

Catalog No. TMO2752Alias Cytidylic Acid, 5'-Cytidylic acid, 5'-CMPCas No. 63-37-6

Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide integral to RNA, comprising the nucleobase cytosine, pentose ribose, and phosphate groups.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	In Stock	In Stock
5 g	$53	-	In Stock
1 mL x 10 mM (in H2O)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.10%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Cytidine 5'-monophosphate AI Summary

Cytidine 5'-monophosphate exhibits a wide range of inhibitory and growth inhibition bioactivities across various assays and cell types. It inhibits alpha-2,3-sialyltransferase and alpha-2,6-sialyltransferase from rat liver with Ki values of 65,000 nM and 64,000 nM, respectively. The compound also displays significant growth inhibition against cultured L1210 mouse leukemia cells (IC50 of 0.35 μM), B16 mouse melanoma cells (IC50 of 1.5 μM), and human leukemia cell line (CCRF-CEM) with an IC50 of 100 nM. For sensitive and multidrug-resistant L1210 leukemia cells, the IC50 values are 430 nM and 410 nM, respectively, indicating similar potency. Additionally, it shows moderate inhibition of UDP-[3H]-GlcNAc import into the Golgi membranes with an IC50 greater than 100,000 nM in one test and 10,000 nM in another. It also exhibits binding energy activity with a calculated binding energy of 5.9 kcal/mol. The compound influences the phosphorylation of human YMPK in Huh7 cells, with a Km value of 56,000 nM, Kcat/Km ratio of 0.54 μM^-1s^-1, and a Kcat value of 30 s^-1. Furthermore, it inhibits bovine seminal ribonuclease and pancreatic ribonuclease A with Ki values of 1,557,900 nM and 844,200 nM, respectively, and shows a binding affinity to Escherichia coli BL21 (DE3) IspF with a Kd of 903,630 nM. Lastly, it exhibits inhibition activity against Plasmodium falciparum ODCase, human ODCase, and Methanobacterium thermoautotrophicum ODCase with Ki values greater than 10,000,000 nM, 1,400,000 nM, and 1,200,000 nM, respectively. These diverse bioactivities suggest its potential for various therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide integral to RNA, comprising the nucleobase cytosine, pentose ribose, and phosphate groups.
Synonyms	Cytidylic Acid, 5'-Cytidylic acid, 5'-CMP

Chemical Properties

Molecular Weight	323.20
Formula	C₉H₁₄N₃O₈P
Cas No.	63-37-6
Smiles	Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1
Relative Density.	2.15 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 7.35 mg/mL (22.74 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.0941 mL	15.4703 mL	30.9406 mL	154.7030 mL
5 mM	0.6188 mL	3.0941 mL	6.1881 mL	30.9406 mL
10 mM	0.3094 mL	1.5470 mL	3.0941 mL	15.4703 mL
20 mM	0.1547 mL	0.7735 mL	1.5470 mL	7.7351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc