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Nomegestrol acetate

Name: Nomegestrol acetate
Brand: TargetMol
SKU: T8395
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8395Cas No. 58652-20-3

Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor

Nomegestrol acetate

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Purity: 99.91%

Catalog No. T8395Cas No. 58652-20-3

Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$47	In Stock	In Stock
10 mg	$74	In Stock	In Stock
25 mg	$145	In Stock	In Stock
50 mg	$226	In Stock	In Stock
100 mg	$341	-	In Stock
200 mg	$488	-	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Nomegestrol acetate AI Summary

Nomegestrol acetate exhibits a diverse range of bioactivities, showcasing its potential as an inhibitor in multiple biological contexts. It is potent in various assays targeting different biological activities, including Schistosoma Mansoni Peroxiredoxins, AmpC Beta-Lactamase, Nrf2, GCN5L2, Histone Lysine Methyltransferase G9a, delayed death inhibitors of the malarial parasite plastid, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and as an antiviral against Foot and Mouth Disease Virus, with potency values ranging from 4610.9 nM to 100000.0 nM. Specifically, Nomegestrol acetate demonstrates antiviral activity against SARS-CoV-2. It showed moderate inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 after 72 hours of treatment, exhibiting an inhibition index of 0.6186. It also inhibited SARS-CoV-2 induced cytotoxicity by 14.66% in Caco-2 cells at a concentration of 10 µM after 48 hours. Additionally, in HRCE cells, the compound exhibited antiviral activity against the SARS-CoV-2 (USA-WA1/2020 strain) with a hit score of 0.2782 at MOI 0.4 after 96 hours. Despite these activities, its inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM was moderate, with an inhibition percentage of 11.84%. The compound was also active in VERO-6 cells with an IC50 greater than 20000.0 nM, indicating a relatively high concentration required for a significant inhibitory effect. Furthermore, Nomegestrol acetate showed inhibition in enzymatic assays of human HDAC6 using different peptide substrates, with inhibition percentages of 41.31% and 1.72%. It also demonstrated high binding affinity towards numerous receptors and transporters in in vitro assays, with significant activities noted: - Inhibition of rat Gabra1 with an AC50 of 2500.0 nM. - High affinity binding to human PGR and AR with AC50 values of 3.0 nM and 20.0 nM, respectively. - Moderate inhibition of human PDE4D with an AC50 of 14000.1 nM. - Inhibition of human NR3C1 with an AC50 of 67.0 nM. In summary, Nomegestrol acetate is a multi-target agent with noteworthy inhibitory and antiviral properties, making it a candidate for further investigation in various biological and therapeutic contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor

Chemical Properties

Molecular Weight	370.48
Formula	C₂₃H₃₀O₄
Cas No.	58652-20-3
Smiles	[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3C(C)=C[C@@]21[H]
Relative Density.	1.16 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (168.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6992 mL	13.4960 mL	26.9920 mL	134.9601 mL
5 mM	0.5398 mL	2.6992 mL	5.3984 mL	26.9920 mL
10 mM	0.2699 mL	1.3496 mL	2.6992 mL	13.4960 mL
20 mM	0.1350 mL	0.6748 mL	1.3496 mL	6.7480 mL
50 mM	0.0540 mL	0.2699 mL	0.5398 mL	2.6992 mL
100 mM	0.0270 mL	0.1350 mL	0.2699 mL	1.3496 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc