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Anti-CD155/PVR Antibody-APC (9R440) is a APC-conjugated Rabbit antibody targeting CD155/PVR. Anti-CD155/PVR Antibody-APC (9R440) can be used in FCM.
Description | Anti-CD155/PVR Antibody-APC (9R440) is a APC-conjugated Rabbit antibody targeting CD155/PVR. Anti-CD155/PVR Antibody-APC (9R440) can be used in FCM. |
Ig Type | Monoclonal Rabbit IgG |
Clone | 9R440 |
Reactivity | Mouse |
Verified Activity | Flow cytometric analysis of PVR (CD155) expression on spleen lymphocytes. BALB/c splenocytes were treated with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 and stained with APC-conjugated anti-Mouse PVR. The histogram were derived from the gated events based on light scattering characteristics of lymphocytes. |
Application | FCM |
Recommended Dose | 10 μl/Test, 0.1 mg/ml |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD155 / PVR (rM CD155 / PVR; TMPY-00762; NP_081790.1; Met1-Arg345) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
Purification | Protein A |
Appearance | Liquid |
Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
Research Background | CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
Conjucates | APC |
Others Formats | Unconjugated/PerCP/FITC/PE |
Antibody Types Available | 5 |
Immunogen | Recombinant Mouse CD155 / PVR protein (TMPY-00762) |
Antigen Species | Mouse |
Biology Area | Cancer Drug Targets |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Transport | Shipping with blue ice. |
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