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Polmacoxib

🥰Excellent
Catalog No. T21294Cas No. 301692-76-2
Alias CG-100649, CG100649, CG 100649

Polmacoxib (CG 100649) is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.

Polmacoxib

Polmacoxib

🥰Excellent
Purity: 97.88%
Catalog No. T21294Alias CG-100649, CG100649, CG 100649Cas No. 301692-76-2
Polmacoxib (CG 100649) is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$39In StockIn Stock
5 mg$64In StockIn Stock
10 mg$109In StockIn Stock
25 mg$183In StockIn Stock
50 mg$272In StockIn Stock
100 mg$397In StockIn Stock
200 mg$593-In Stock
1 mL x 10 mM (in DMSO)$70In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:97.88%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Polmacoxib (CG 100649) is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.
Targets&IC50
COX-2:0.1 μg/mL (IC50)
SynonymsCG-100649, CG100649, CG 100649
Chemical Properties
Molecular Weight361.39
FormulaC18H16FNO4S
Cas No.301692-76-2
SmilesCC1(C)OC(=C(C1=O)c1cccc(F)c1)c1ccc(cc1)S(N)(=O)=O
Relative Density.1.361 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: Insoluble
DMSO: 55 mg/mL (152.19 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7671 mL13.8355 mL27.6709 mL138.3547 mL
5 mM0.5534 mL2.7671 mL5.5342 mL27.6709 mL
10 mM0.2767 mL1.3835 mL2.7671 mL13.8355 mL
20 mM0.1384 mL0.6918 mL1.3835 mL6.9177 mL
50 mM0.0553 mL0.2767 mL0.5534 mL2.7671 mL
100 mM0.0277 mL0.1384 mL0.2767 mL1.3835 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

tumorpolypPolmacoxiborthotopicNSAIDInhibitorinhibitinflammatoryCyclooxygenaseCOX-2COXcolorectalCarbonicAnhydraseCarbonic Anhydrasecarbonic anhydraseCarbonate dehydrataseadenoma
Related Tags: buy Polmacoxib | purchase Polmacoxib | Polmacoxib cost | order Polmacoxib | Polmacoxib chemical structure | Polmacoxib formula | Polmacoxib molecular weight
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