Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = <40, 180, <400, 110, and <400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by calcitriol in HL-60 and U937 leukemia cells when used at a concentration of 5 μM.2Tpl2 kinase inhibitor (5 μM) inhibits the proliferation of KG-1a leukemia cells.3
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 143.00 | |
5 mg | 35 days | $ 550.00 | |
10 mg | 35 days | $ 755.00 | |
25 mg | 35 days | $ 1,710.00 |
Description | Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by calcitriol in HL-60 and U937 leukemia cells when used at a concentration of 5 μM.2Tpl2 kinase inhibitor (5 μM) inhibits the proliferation of KG-1a leukemia cells.3 |
Molecular Weight | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: Slightly soluble
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. More
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Tpl2 Kinase Inhibitor (hydrochloride) Tpl-2 Kinase Inhibitor (hydrochloride) Tpl2 Kinase Inhibitor inhibitor inhibit