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Oxybuprocaine hydrochloride

Name: Oxybuprocaine hydrochloride
Brand: TargetMol
SKU: T0378
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0378Cas No. 5987-82-6

Alias Risedronic Acid, Oxybuprocaine HCl, Benoxinate Hydrochloride

Oxybuprocaine hydrochloride (Oxybuprocaine HCl), a local anesthetic, is used especially in otolaryngology and ophthalmology.

Oxybuprocaine hydrochloride

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Catalog No. T0378Alias Risedronic Acid, Oxybuprocaine HCl, Benoxinate HydrochlorideCas No. 5987-82-6

Oxybuprocaine hydrochloride (Oxybuprocaine HCl), a local anesthetic, is used especially in otolaryngology and ophthalmology.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	In Stock	In Stock
25 mg	$48	In Stock	In Stock
50 mg	$60	In Stock	In Stock
100 mg	$93	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Oxybuprocaine hydrochloride AI Summary

Oxybuprocaine hydrochloride is a multifunctional compound demonstrating a wide range of bioactivities. It acts as a potent inhibitor of AmpC Beta-Lactamase (1412.5 nM), BAZ2B (707.9 nM), the malarial parasite plastid with delayed death (1168.9 nM), and Hepatitis C Virus (2818.4 nM). Additionally, it induces DNA re-replication in SW480 colon adenocarcinoma cells (631.0 nM) and serves as a GLP-1 receptor inverse agonist (3548.1 nM). Oxybuprocaine hydrochloride also inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) both without CPT (8052.4 nM) and with CPT (12762.2 nM), and is a potent inhibitor of RAD52 (33920.0 nM). It effectively blocks the entry of the Ebola virus via various screening channels (AC50 ranging from 17.78 μM to 31622.8 nM) and inhibits insulin secretion from INS-1E cells in the presence of glucose (IC50 = 15505.47 nM). In terms of antiviral activity against SARS-CoV-2, Oxybuprocaine hydrochloride exhibits moderate inhibition of cell viability in Vero E6 cells infected with the virus (strain BavPat1) at a low MOI of 0.002 after 72 hours, with an inhibition index of 1.193. It also inhibits cytotoxicity in Caco-2 cells, showing a 7.22% inhibition at 10 μM concentration after 48 hours. In SARS-CoV-2 3CL-Pro protease inhibition assays, Oxybuprocaine hydrochloride inhibits 5.372% at 20 μM using a FRET response from a peptide substrate. Moreover, it shows antiviral activity by reducing SARS-CoV-2 induced cytotoxicity in VERO-6 cells at a 10 μM concentration after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus, with an inhibition rate of 0.1%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oxybuprocaine hydrochloride (Oxybuprocaine HCl), a local anesthetic, is used especially in otolaryngology and ophthalmology.
In vivo	Similar to bupivacaine or lidocaine, Oxybuprocaine produces dose-related spinal cord blockade of proprioception, locomotion, and injury perception.Oxybuprocaine binds to sodium channels and reversibly stabilizes neuronal cell membranes to make them less permeable to sodium ions.Oxybuprocaine inhibits the depolarization of neuronal cell membranes, thereby Oxybuprocaine inhibits the depolarization of neuronal cell membrane, thus blocking the initiation and conduction of nerve impulses.
Synonyms	Risedronic Acid, Oxybuprocaine HCl, Benoxinate Hydrochloride

Chemical Properties

Molecular Weight	344.88
Formula	C₁₇H₂₉ClN₂O₃
Cas No.	5987-82-6
Smiles	Cl.CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 64 mg/mL (185.57 mM), Sonication is recommended.

H2O: 63 mg/mL (182.67 mM), Sonication is recommended.

DMSO: 64 mg/mL (185.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8996 mL	14.4978 mL	28.9956 mL	144.9780 mL
5 mM	0.5799 mL	2.8996 mL	5.7991 mL	28.9956 mL
10 mM	0.2900 mL	1.4498 mL	2.8996 mL	14.4978 mL
20 mM	0.1450 mL	0.7249 mL	1.4498 mL	7.2489 mL
50 mM	0.0580 mL	0.2900 mL	0.5799 mL	2.8996 mL
100 mM	0.0290 mL	0.1450 mL	0.2900 mL	1.4498 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc