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Jatrorrhizine hydrochloride
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Catalog No. T2986Cas No. 960383-96-4
Jatrorrhizine hydrochloride is a compound extracted from the roots of Berberis vulgaris with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities.Jatrorrhizine hydrochloride is an orally active and selective inhibitor of acetylcholinesterase (AChE), which inhibits norepinephrine (NE) uptake. It inhibits the uptake of norepinephrine (NE).
Jatrorrhizine hydrochloride
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Purity: 99.22%
Catalog No. T2986Cas No. 960383-96-4
Jatrorrhizine hydrochloride is a compound extracted from the roots of Berberis vulgaris with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities.Jatrorrhizine hydrochloride is an orally active and selective inhibitor of acetylcholinesterase (AChE), which inhibits norepinephrine (NE) uptake. It inhibits the uptake of norepinephrine (NE).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 20 mg | $50 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.22%
Color:Yellow
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Product Introduction
Jatrorrhizine hydrochloride AI Summary
Jatrorrhizine hydrochloride exhibits a broad spectrum of bioactivities, most notably antimalarial and anti-HIV activities. It shows significant in vitro antimalarial activity against Plasmodium falciparum strains D6 and W2 with IC50 values of 0.422 ug/mL and 1.607 ug/mL, respectively. Additionally, it demonstrates antiplasmodial activity against the multi-drug-resistant Plasmodium falciparum K1 strain with an IC50 of 3150.0 nM and against the drug-susceptible 3D7 strain with an EC50 of 939.0 nM. In terms of HIV inhibition, Jatrorrhizine hydrochloride inhibits HIV1 reverse transcriptase activity with an IC50 of 71.0 ug/mL. The compound also displays antiamnesic activity against Entamoeba histolytica NIH 200 and some cytotoxicity towards human KB cells and Huh7 hepatocellular carcinoma cells, with IC50 values of 82700.0 nM and 8940.0 nM, respectively. Furthermore, it exhibits estrogenic activity at ERalpha in human MVLN cells, with activities of 71.19% at 100 ug/mL and 52.2% at 20 ug/mL. In terms of physicochemical properties, Jatrorrhizine hydrochloride has varying solubility levels in different pH conditions (1300000.0 nM to 1500000.0 nM), log P values ranging from 0.1 to -1.5, log D values from -1.5 to 0.6, a binding affinity to bovine serum albumin with a Kb value of 1.73 x 10^-3 L/mol, and a dissociation constant pKa of 9.6..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Jatrorrhizine hydrochloride is a compound extracted from the roots of Berberis vulgaris with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities.Jatrorrhizine hydrochloride is an orally active and selective inhibitor of acetylcholinesterase (AChE), which inhibits norepinephrine (NE) uptake. It inhibits the uptake of norepinephrine (NE). |
| Molecular Weight | 373.83 |
| Formula | C20H20ClNO4 |
| Cas No. | 960383-96-4 |
| Smiles | c12c(c(c(cc1)OC)OC)c[n+]1c(c2)c2c(CC1)cc(c(c2)OC)O.[Cl-] |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 3.33 mg/mL (8.91 mM), Sonication is recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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