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Anti-MIG6 Polyclonal Antibody
😃Good
Catalog No. TMAB-08820
Anti-MIG6 Polyclonal Antibody is a Rabbit antibody targeting MIG6. Anti-MIG6 Polyclonal Antibody can be used in WB.
Anti-MIG6 Polyclonal Antibody
Anti-MIG6 Polyclonal Antibody
😃Good
Catalog No. TMAB-08820
Anti-MIG6 Polyclonal Antibody is a Rabbit antibody targeting MIG6. Anti-MIG6 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-MIG6 Polyclonal Antibody is a Rabbit antibody targeting MIG6. Anti-MIG6 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Dog,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| Concentration | 1mg/ml |
| Research Background | ERRFI1 belongs to a class of mammalian regulators of tyrosine kinase signalling, whose expression is trascriptionally controlled by receptor activation. A number of features reveal this protein as a canidate for being a signal transducing protein; proline rich sequences, consensus sequences for phosphorylation of ERK1 and ERK2, a potential binding site for 14-3-3 proteins and other potential sites for phosphorylation by protein kinase C, A and Casein kinase II. |
| Immunogen | KLH conjugated synthetic peptide: human MIG6 |
| Antigen Species | Human |
| Gene Name | ERRFI1 |
| Gene ID | |
| Protein Name | ERBB receptor feedback inhibitor 1 |
| Uniprot ID | |
| Function | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development |
| Molecular Weight | Theoretical: 51 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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