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Pipemidic acid

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Catalog No. T0396Cas No. 51940-44-4
Alias Acido pipemidico

Pipemidic acid (Acido pipemidico), a new antibacterial agent, inhibits the activity of Pseudomonas aeruginosa.

Pipemidic acid

Pipemidic acid

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Purity: 99.65%
Catalog No. T0396Alias Acido pipemidicoCas No. 51940-44-4
Pipemidic acid (Acido pipemidico), a new antibacterial agent, inhibits the activity of Pseudomonas aeruginosa.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 mg$34In Stock-
500 mg$55In Stock-
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.65%
Appearance:Solid
Color:White
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Product Introduction

Pipemidic acid AI Summary
Pipemidic acid exhibits a range of bioactivities, including significant antibacterial, antiviral, and antimalarial effects. It shows potent in vitro antibacterial activity against various clinical isolates, with MIC values ranging from 0.39 to 31.2 µg/mL against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Bacillus subtilis, Salmonella typhimurium, and Micrococcus luteus. However, it has limited efficacy against certain strains of Staphylococcus aureus and Pseudomonas aeruginosa with MIC values greater than 16.0 µg/mL and 25.0 µg/mL, respectively. Additionally, Pipemidic acid demonstrates moderate antiviral activity against SARS-CoV-2, inhibiting viral cytotoxicity in cell assays with an IC50 value above 20,000 nM. The compound also shows moderate antimalarial activity against Plasmodium parasites, with IC50 values of 10.5 µg/mL against the blood stage of chloroquine-sensitive Plasmodium falciparum NF54-R strain and above 100 µg/mL against the hepatic stage of Plasmodium yoelii yoelii 265 BY. Furthermore, it is involved in inhibiting DNA gyrase, human HDAC6 enzyme, and the SARS-CoV-2 3CL-Pro protease. Pipemidic acid is associated with hepatotoxicity under specific conditions and has influenced bioactivities in assays related to USP1/UAF1 inhibitors and PhoP region inhibition in Salmonella. The compound’s lipophilicity and its performance in assays related to the inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells have also been noted..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Pipemidic acid (Acido pipemidico), a new antibacterial agent, inhibits the activity of Pseudomonas aeruginosa.
SynonymsAcido pipemidico
Chemical Properties
Molecular Weight303.32
FormulaC14H17N5O3
Cas No.51940-44-4
SmilesC(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CN=C(N2)N3CCNCC3
Relative Density.1.38g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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