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Trovirdine

Name: Trovirdine
Brand: TargetMol
SKU: T3172
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3172Cas No. 149488-17-5

Alias LY300046

Trovirdine (LY300046) is a thiourea non-nucleoside reverse transcriptase inhibitor.

Trovirdine

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Purity: 98.50%

Catalog No. T3172Alias LY300046Cas No. 149488-17-5

Trovirdine (LY300046) is a thiourea non-nucleoside reverse transcriptase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	In Stock	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$328	In Stock	In Stock
100 mg	$496	-	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.50%

Color:White

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Product Introduction

Trovirdine AI Summary

Trovirdine exhibits significant bioactivity against HIV-1, demonstrating potent inhibition of both wild-type and certain mutant strains of the virus. It shows effective inhibition of purified recombinant HIV-1 reverse transcriptase (RT) with an IC50 of 800.0 nM and an even more potent inhibition of viral replication in peripheral blood mononuclear cells (PBMCs) with IC50 values of 7.0 nM for the wild-type strain and 20.0 nM for the RT-MDR strain. The compound also displays strong antiviral activity in MT-4 cells infected with wild-type HIV-1, with an EC50 of 20.0 nM, and shows high selectivity with an SI of 3000, indicating a favorable therapeutic profile. Trovirdine appears less effective against certain resistant RT mutants such as Y181C, with an IC50 value of 500.0 nM, and significantly reduced efficacy against the Y181C/K103N mutations, with an IC50 exceeding 100,000.0 nM. It demonstrates no substantial cytotoxic effects in mock-infected MT-4 cells with a CC50 greater than 100,000.0 nM. Furthermore, Trovirdine shows minor activity against SARS-CoV-2 and human HDAC6 enzyme but is primarily noted for its potential as a novel HIV treatment candidate due to its multi-stage inhibitory activity in the viral life cycle and high selectivity index..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Trovirdine (LY300046) is a thiourea non-nucleoside reverse transcriptase inhibitor.
Targets&IC50	HIV-1 RT:7 nM
Synonyms	LY300046

Chemical Properties

Molecular Weight	337.24
Formula	C₁₃H₁₃BrN₄S
Cas No.	149488-17-5
Smiles	Brc1ccc(NC(=S)NCCc2ccccn2)nc1
Relative Density.	1.539g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (163.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9652 mL	14.8262 mL	29.6525 mL	148.2624 mL
5 mM	0.5930 mL	2.9652 mL	5.9305 mL	29.6525 mL
10 mM	0.2965 mL	1.4826 mL	2.9652 mL	14.8262 mL
20 mM	0.1483 mL	0.7413 mL	1.4826 mL	7.4131 mL
50 mM	0.0593 mL	0.2965 mL	0.5930 mL	2.9652 mL
100 mM	0.0297 mL	0.1483 mL	0.2965 mL	1.4826 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc