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Anti-NR5A2 Antibody (5J673)

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Catalog No. TMAB-09625

Anti-NR5A2 Antibody (5J673) is a Rabbit antibody targeting NR5A2. Anti-NR5A2 Antibody (5J673) can be used in WB.

Anti-NR5A2 Antibody (5J673)

Anti-NR5A2 Antibody (5J673)

😃Good
Catalog No. TMAB-09625
Anti-NR5A2 Antibody (5J673) is a Rabbit antibody targeting NR5A2. Anti-NR5A2 Antibody (5J673) can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1487-10 days7-10 days
50 μL$2627-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-NR5A2 Antibody (5J673) is a Rabbit antibody targeting NR5A2. Anti-NR5A2 Antibody (5J673) can be used in WB.
Ig Type
IgG
Clone
5J673
Reactivity
Human,Mouse,Rat
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
Tissue SpecificityAbundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in hepG2. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and hepG2 cells.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundNuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex.
Antigen Details
Immunogen
A synthesized peptide: human NR5A2
Antigen Species
Human
Gene Name
NR5A2
Gene ID
2494
Protein Name
Nuclear receptor subfamily 5 group A member 2
Uniprot ID
O00482
Function
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
Chemical Properties
Molecular WeightTheoretical: 61 kDa. Actual: 65 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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