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Anti-GLCNE Antibody (4K747)
Catalog No. TMAB-06500 Copy Product Info
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Anti-GLCNE Antibody (4K747) is a Rabbit antibody targeting GLCNE. Anti-GLCNE Antibody (4K747) can be used in WB,ICC/IF.
Anti-GLCNE Antibody (4K747)
Copy Product Info🥰Excellent
Catalog No. TMAB-06500
Anti-GLCNE Antibody (4K747) is a Rabbit antibody targeting GLCNE. Anti-GLCNE Antibody (4K747) can be used in WB,ICC/IF.
Anti-GLCNE Antibody
(4K747)
(4K747)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-GLCNE Antibody (4K747) is a Rabbit antibody targeting GLCNE. Anti-GLCNE Antibody (4K747) can be used in WB,ICC/IF. |
| Ig Type | IgG |
| Clone | 4K747 |
| Reactivity | Human |
| Verified Activity | 25 ug total protein per lane of various lysates (see on figure) probed with GLCNE monoclonal antibody, unconjugated (TMAB-06500) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasmic |
| Tissue Specificity | Highest expression in liver and placenta. Also found in heart, brain, lung, kidney, skeletal muscle and pancreas. Isoform 1 is expressed in heart, brain, kidney, liver, placenta, lung, spleen, pancreas, skeletal muscle and colon. Isoform 2 is expressed mainly in placenta, but also in brain, kidney, liver, lung, pancreas and colon. Isoform 3 is expressed at low level in kidney, liver, placenta and colon. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Bifunctional enzyme that possesses both UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities, and serves as the initiator of the biosynthetic pathway leading to the production of N-acetylneuraminic acid (NeuAc), a critical precursor in the synthesis of sialic acids. By catalyzing this pivotal and rate-limiting step in sialic acid biosynthesis, this enzyme assumes a pivotal role in governing the regulation of cell surface sialylation. |
| Immunogen | A synthesized peptide: human GNE |
| Antigen Species | Human |
| Gene Name | GNE |
| Gene ID | |
| Protein Name | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase |
| Uniprot ID | |
| Function | Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. |
| Molecular Weight | Theoretical: 79 kDa. Actual: 75 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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