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Anti-GLCNE Antibody (4K747)
😃Good
Catalog No. TMAB-06500
Anti-GLCNE Antibody (4K747) is a Rabbit antibody targeting GLCNE. Anti-GLCNE Antibody (4K747) can be used in WB,ICC/IF.
Anti-GLCNE Antibody (4K747)
Anti-GLCNE Antibody (4K747)
😃Good
Catalog No. TMAB-06500
Anti-GLCNE Antibody (4K747) is a Rabbit antibody targeting GLCNE. Anti-GLCNE Antibody (4K747) can be used in WB,ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-GLCNE Antibody (4K747) is a Rabbit antibody targeting GLCNE. Anti-GLCNE Antibody (4K747) can be used in WB,ICC/IF. |
| Ig Type | IgG |
| Clone | 4K747 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasmic |
| Tissue Specificity | Highest expression in liver and placenta. Also found in heart, brain, lung, kidney, skeletal muscle and pancreas. Isoform 1 is expressed in heart, brain, kidney, liver, placenta, lung, spleen, pancreas, skeletal muscle and colon. Isoform 2 is expressed mainly in placenta, but also in brain, kidney, liver, lung, pancreas and colon. Isoform 3 is expressed at low level in kidney, liver, placenta and colon. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Bifunctional enzyme that possesses both UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities, and serves as the initiator of the biosynthetic pathway leading to the production of N-acetylneuraminic acid (NeuAc), a critical precursor in the synthesis of sialic acids. By catalyzing this pivotal and rate-limiting step in sialic acid biosynthesis, this enzyme assumes a pivotal role in governing the regulation of cell surface sialylation. |
| Immunogen | A synthesized peptide: human GNE |
| Antigen Species | Human |
| Gene Name | GNE |
| Gene ID | |
| Protein Name | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase |
| Uniprot ID | |
| Function | Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. |
| Molecular Weight | Theoretical: 79 kDa. Actual: 75 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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