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Opiranserin hydrochloride

Name: Opiranserin hydrochloride
Brand: TargetMol
SKU: T9833
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9833Cas No. 1440796-75-7

Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.

Opiranserin hydrochloride

🥰Excellent

Purity: 99.33%

Catalog No. T9833Cas No. 1440796-75-7

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$239	In Stock
10 mg	$378	In Stock
25 mg	$687	In Stock
50 mg	$977	In Stock
100 mg	$1,360	In Stock
500 mg	$2,730	In Stock
1 mL x 10 mM (in DMSO)	$263	In Stock

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Purity:99.33%

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Product Introduction

Bioactivity

Description	Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.
Targets&IC50	GlyT2:0.86 μM, 5-HT2A receptor:1.3 μM, P2X3 (rat):0.87 μM

Chemical Properties

Molecular Weight	430.97
Formula	C₂₁H₃₅ClN₂O₅
Cas No.	1440796-75-7
Smiles	Cl.CCCCOc1c(OC)cc(cc1OC)C(=O)NCC1(CCOCC1)N(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (116.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3203 mL	11.6017 mL	23.2035 mL	116.0174 mL
5 mM	0.4641 mL	2.3203 mL	4.6407 mL	23.2035 mL
10 mM	0.2320 mL	1.1602 mL	2.3203 mL	11.6017 mL
20 mM	0.1160 mL	0.5801 mL	1.1602 mL	5.8009 mL
50 mM	0.0464 mL	0.2320 mL	0.4641 mL	2.3203 mL
100 mM	0.0232 mL	0.1160 mL	0.2320 mL	1.1602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc