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Anti-Integrin alpha 5 Antibody (8Y946)
😃Good
Catalog No. TMAB-07742
Anti-Integrin alpha 5 Antibody (8Y946) is a Rabbit antibody targeting Integrin alpha 5. Anti-Integrin alpha 5 Antibody (8Y946) can be used in WB,IHC-P,IHC-Fr,IF,IP.
Anti-Integrin alpha 5 Antibody (8Y946)
Anti-Integrin alpha 5 Antibody (8Y946)
😃Good
Catalog No. TMAB-07742
Anti-Integrin alpha 5 Antibody (8Y946) is a Rabbit antibody targeting Integrin alpha 5. Anti-Integrin alpha 5 Antibody (8Y946) can be used in WB,IHC-P,IHC-Fr,IF,IP.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Integrin alpha 5 Antibody (8Y946) is a Rabbit antibody targeting Integrin alpha 5. Anti-Integrin alpha 5 Antibody (8Y946) can be used in WB,IHC-P,IHC-Fr,IF,IP. |
| Ig Type | IgG |
| Clone | 8Y946 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200; IP: 1:20-50 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. |
| Immunogen | A synthesized peptide: human Integrin alpha 5 |
| Antigen Species | Human |
| Gene Name | ITGA5 |
| Gene ID | |
| Protein Name | Integrin alpha-5 |
| Uniprot ID | |
| Function | CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. |
| Molecular Weight | Theoretical: 115 kDa. Actual: 150 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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