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4-Allylcatechol

Name: 4-Allylcatechol
Brand: TargetMol
SKU: TN1274
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1274Cas No. 1126-61-0

Alias Hydroxychavicol, 4-Allylpyrocatechol

4-Allylcatechol (Hydroxychavicol) has antioxidant activity, it has protective activity against the photosensitization-induced damage to lipids and proteins of rat liver mitochondria, which attributes to its free radical and singlet oxygen scavenging properties.

4-Allylcatechol

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Purity: 97.94%

Catalog No. TN1274Alias Hydroxychavicol, 4-AllylpyrocatecholCas No. 1126-61-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$51	In Stock	In Stock
25 mg	$105	In Stock	In Stock
50 mg	$172	In Stock	In Stock
100 mg	$278	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:97.94%

Appearance:Solid

Color:Purple

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COA GC HNMR LCMS

Product Introduction

4-Allylcatechol AI Summary

4-Allylcatechol exhibits a broad range of bioactivities, including inhibitory, cytotoxic, protective, antimicrobial, antioxidant, and anti-inflammatory effects. It inhibits beta-hexosaminidase release from RBL-2H3 cells with an IC50 greater than 100,000 nM and reduces nitric oxide production in LPS-activated mouse peritoneal macrophages at 15,000 nM. The compound shows cytotoxicity against mouse L929 cells at 20 uM with a survival rate of 75.7% and significant cytotoxic effects against human NUGC, HeLa, and PC3 cells. In particular, it inhibits the growth of HeLa cells with an IC50 of 83,000 nM and PC3 cells with an IC50 of 55,000 nM. Moreover, 4-Allylcatechol exhibits antimicrobial activity against various oral pathogens and is effective in reducing bacterial growth and biofilm formation. It also shows nematocidal activity against Caenorhabditis elegans with a MEC of 300 ug/ml. The compound possesses antioxidant activity, as evidenced by its ability to reduce lipid peroxidation in rat liver microsomes and scavenge radicals in different assays. Additionally, it demonstrates metal chelating activity and has shown potential to inhibit xanthine oxidase with an IC50 of 16,700 nM. 4-Allylcatechol also displays alpha-glucosidase inhibitory activity and exhibits anti-inflammatory properties in murine RAW264.7 cells by inhibiting NO production at an IC50 of 4,800 nM. Overall, 4-Allylcatechol is a multifunctional molecule with significant potential in therapeutic applications due to its diverse biological activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	4-Allylcatechol (Hydroxychavicol) has antioxidant activity, it has protective activity against the photosensitization-induced damage to lipids and proteins of rat liver mitochondria, which attributes to its free radical and singlet oxygen scavenging properties.
Synonyms	Hydroxychavicol, 4-Allylpyrocatechol

Chemical Properties

Molecular Weight	150.17
Formula	C₉H₁₀O₂
Cas No.	1126-61-0
Smiles	Oc1ccc(CC=C)cc1O
Relative Density.	1.148 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (665.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (26.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.6591 mL	33.2956 mL	66.5912 mL	332.9560 mL
5 mM	1.3318 mL	6.6591 mL	13.3182 mL	66.5912 mL
10 mM	0.6659 mL	3.3296 mL	6.6591 mL	33.2956 mL
20 mM	0.3330 mL	1.6648 mL	3.3296 mL	16.6478 mL
50 mM	0.1332 mL	0.6659 mL	1.3318 mL	6.6591 mL
100 mM	0.0666 mL	0.3330 mL	0.6659 mL	3.3296 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc