Shopping Cart
- Remove All
- Your shopping cart is currently empty
Anti-CEACAM5 Antibody (6E182) is a Mouse antibody targeting CEACAM5. Anti-CEACAM5 Antibody (6E182) can be used in ELISA(Det).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μL | $69 | 7-10 days | |
100 μL | $199 | 7-10 days |
Description | Anti-CEACAM5 Antibody (6E182) is a Mouse antibody targeting CEACAM5. Anti-CEACAM5 Antibody (6E182) can be used in ELISA(Det). |
Alias | CEA, CD66e, carcinoembryonic antigen-related cell adhesion molecule 5 |
Ig Type | Monoclonal Mouse IgG2a |
Clone | 6E182 |
Reactivity | Human |
Application | ELISA(Det) |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CEACAM5 / CEA / CD66e (rh CEACAM5 / CEA / CD66e; TMPY-01647; NP_004354.2; Met1-Ala685). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | CEACAM5, also known as CEA or CD66e, belongs to the large CEACAM subfamily of the immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with an MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domains and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
Conjucates | Unconjugated |
Others Formats | Biotin/HRP |
Antibody Types Available | 3 |
Immunogen | Recombinant Human CEACAM5 / CEA / CD66e Protein (TMPY-01647) |
Antigen Species | Human |
Biology Area | Cancer Drug Targets |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.