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Anti-GRM2+GRM4 Polyclonal Antibody

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Catalog No. TMAB-06792

Anti-GRM2+GRM4 Polyclonal Antibody is a Rabbit antibody targeting GRM2+GRM4. Anti-GRM2+GRM4 Polyclonal Antibody can be used in WB.

Anti-GRM2+GRM4 Polyclonal Antibody

Anti-GRM2+GRM4 Polyclonal Antibody

😃Good
Catalog No. TMAB-06792
Anti-GRM2+GRM4 Polyclonal Antibody is a Rabbit antibody targeting GRM2+GRM4. Anti-GRM2+GRM4 Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-GRM2+GRM4 Polyclonal Antibody is a Rabbit antibody targeting GRM2+GRM4. Anti-GRM2+GRM4 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat)
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue SpecificityWidely expressed in different regions of the adult brain as well as in fetal brain.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human GRM2+GRM4
Antigen Species
Human
Gene Name
GRM2
Gene ID
2912
Protein Name
Metabotropic glutamate receptor 2
Uniprot ID
Q14416
Function
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Chemical Properties
Molecular WeightTheoretical: 102 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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