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Anti-MADD Antibody (3F623)
😃Good
Catalog No. TMAB-08504
Anti-MADD Antibody (3F623) is a Rabbit antibody targeting MADD. Anti-MADD Antibody (3F623) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-MADD Antibody (3F623)
Anti-MADD Antibody (3F623)
😃Good
Catalog No. TMAB-08504
Anti-MADD Antibody (3F623) is a Rabbit antibody targeting MADD. Anti-MADD Antibody (3F623) can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-MADD Antibody (3F623) is a Rabbit antibody targeting MADD. Anti-MADD Antibody (3F623) can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 3F623 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; IF: 1:100-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane. |
| Tissue Specificity | Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family.Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. |
| Immunogen | A synthesized peptide: human MADD |
| Antigen Species | Human |
| Gene Name | MADD |
| Gene ID | |
| Protein Name | MAP kinase-activating death domain protein |
| Uniprot ID | |
| Function | Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. |
| Molecular Weight | Theoretical: 183 kDa. Actual: 230 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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