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Dilazep dihydrochloride

Name: Dilazep dihydrochloride
Brand: TargetMol
SKU: T15130
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15130Cas No. 20153-98-4

Dilazep dihydrochloride is an adenosine uptake inhibitor. Dilazep dihydrochloride also inhibits the ischemic damage, membrane transport of nucleosides and platelet aggregation. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine.

Dilazep dihydrochloride

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Purity: 98.39%

Catalog No. T15130Cas No. 20153-98-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$213	In Stock	In Stock
100 mg	$347	In Stock	In Stock
200 mg	$498	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.39%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Dilazep dihydrochloride is an adenosine uptake inhibitor. Dilazep dihydrochloride also inhibits the ischemic damage, membrane transport of nucleosides and platelet aggregation. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine.
In vitro	Dilazep, NBI and Dipyridamole have been reported to inhibit the uptake of adenosine into different cells. The uptake mechanism has been studied extensively in vitro. In these compounds, Dilazep and NBI are almost 10 times more effective than Dipyridamole. Only Dilazep is water soluble and no solubility aiding organic solvent is needed for preparing an aqueous solution[1].
In vivo	Dilazep acts by inhibiting phospholipase activation in reperfused heart mitochondria and preventing lipid peroxidation in cerebral ischemia and reperfusion, potentially reducing ischemic cerebral injury through increased cerebral blood flow and protection of vascular endothelial cell membranes. Importantly, low doses (0.04-0.1 mg/kg/min) amplify the effects of adenosine, significantly enhancing superior mesenteric arterial conductance (SMAC) and raising arterial plasma adenosine levels, with a clear correlation observed between adenosine levels and SMAC changes, showing a 193.4% change in SMAC and an EC50 value of 2.8 μM. However, the vasodilatory potentiation by Dilazep is nullified by 8-phenyltheophylline, though this does not interfere with isoproterenol-induced relaxation.

Chemical Properties

Molecular Weight	677.61
Formula	C₃₁H₄₆Cl₂N₂O₁₀
Cas No.	20153-98-4
Smiles	Cl.Cl.COc1cc(cc(OC)c1OC)C(=O)OCCCN1CCCN(CCCOC(=O)c2cc(OC)c(OC)c(OC)c2)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 71.4 mg/mL (105.37 mM), Sonication is recommended.

H2O: 80 mg/mL (118.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.4758 mL	7.3789 mL	14.7578 mL	73.7888 mL
5 mM	0.2952 mL	1.4758 mL	2.9516 mL	14.7578 mL
10 mM	0.1476 mL	0.7379 mL	1.4758 mL	7.3789 mL
20 mM	0.0738 mL	0.3689 mL	0.7379 mL	3.6894 mL
50 mM	0.0295 mL	0.1476 mL	0.2952 mL	1.4758 mL
100 mM	0.0148 mL	0.0738 mL	0.1476 mL	0.7379 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc