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Caftaric acid

Name: Caftaric acid
Brand: TargetMol
SKU: T3S2390
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S2390Cas No. 67879-58-7

Alias trans-Caftaric acid

Caftaric acid (trans-Caftaric acid) is a natural product with antioxidant and anti-inflammatory properties, antimutagenicity, and an inhibitor of protein-protein interactions mediated by Src family kinases.

Caftaric acid

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Purity: 99.50%

Catalog No. T3S2390Alias trans-Caftaric acidCas No. 67879-58-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
2 mg	$40	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$328	In Stock	In Stock
100 mg	$492	In Stock	In Stock
200 mg	$688	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.50%

Color:White to Yellow

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Caftaric acid AI Summary

Caftaric acid shows bioactivities related to inhibiting SH2 domains of various proteins and kinases. It inhibits the LCK SH2 domain with an IC50 of 118000.0 nM, c-SRC SH2 domain with an IC50 of 74000.0 nM, and STAT1, STAT3, and STAT5b SH2 domains at 200 µM with inhibition percentages of 19.0%, 30.0%, and 31.2%, respectively. It also exhibits cytotoxicity against human MT2 cells and antiviral activity against HIV LAI, with an EC50 of 80500.0 nM for protecting against virus-induced cytopathic effects. Additionally, it inhibits HIV NL4-3 recombinant integrase strand transfer activity and 3'-end processing activity with IC50 values of 6080.0 nM and 19100.0 nM, respectively. Furthermore, Caftaric acid significantly induces glucose-stimulated insulin secretion in NMRI mouse pancreatic islets in a dose-dependent manner, suggesting potential bioactivity in regulating insulin release..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Caftaric acid (trans-Caftaric acid) is a natural product with antioxidant and anti-inflammatory properties, antimutagenicity, and an inhibitor of protein-protein interactions mediated by Src family kinases.
Synonyms	trans-Caftaric acid

Chemical Properties

Molecular Weight	312.23
Formula	C₁₃H₁₂O₉
Cas No.	67879-58-7
Smiles	O[C@H]([C@@H](OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O)C(O)=O
Relative Density.	1.694 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (384.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2028 mL	16.0138 mL	32.0277 mL	160.1384 mL
5 mM	0.6406 mL	3.2028 mL	6.4055 mL	32.0277 mL
10 mM	0.3203 mL	1.6014 mL	3.2028 mL	16.0138 mL
20 mM	0.1601 mL	0.8007 mL	1.6014 mL	8.0069 mL
50 mM	0.0641 mL	0.3203 mL	0.6406 mL	3.2028 mL
100 mM	0.0320 mL	0.1601 mL	0.3203 mL	1.6014 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc