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PDGFB Protein, Human, Recombinant (His)

Catalog No. TMPY-04644
Synonyms: platelet-derived growth factor beta polypeptide, SSV, c-sis, SIS, PDGF-2, IBGC5, PDGF2, platelet-derived growth factor β polypeptide

Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 14.3 kDa and the accession number is P01127-2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
PDGFB Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
50 μg In stock $ 386.00
1 mg 5 days $ 3,520.00
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Biological Description
Technical Params
Product Properties
Biological Information Measured by its binding ability in a functional ELISA. Immobilized Human PDGF-B His at 2 μg/ml (100 μl/well) can bind Human PDGFRBHis & hFc, the EC50 of Human PDGFRBHis & hFc is 9.0-40.0 ng/mL.

Description Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 14.3 kDa and the accession number is P01127-2.
Species Human
Expression System P. pastoris (Yeast)
Tag N-His
Accession Number P01127-2
Synonyms platelet-derived growth factor beta polypeptide, SSV, c-sis, SIS, PDGF-2, IBGC5, PDGF2, platelet-derived growth factor β polypeptide
Construction Human PDGFB (NP_148937.1) (Ser82-Thr190)
Protein Purity > 95 % as determined by SDS-PAGE.

Molecular Weight 14.3 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Supplied as sterile PBS, 25% Glycerol, pH 7.4.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor.

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Keywords

PDGFB Protein, Human, Recombinant (His) platelet-derived growth factor beta polypeptide SSV c-sis SIS IBGC 5 PDGF-2 IBGC5 PDGF2 PDGF 2 platelet-derived growth factor β polypeptide IBGC-5 platelet-derived growth factor b polypeptide recombinant recombinant-proteins proteins protein

 

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