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DDO-5936 is a potent and specific inhibitor of the protein-protein interaction (PPI) between HSP90 and Cdc37.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $31 | In Stock | In Stock | |
| 5 mg | $73 | In Stock | In Stock | |
| 10 mg | $128 | In Stock | In Stock | |
| 25 mg | $278 | In Stock | In Stock | |
| 50 mg | $410 | In Stock | In Stock | |
| 100 mg | $583 | In Stock | In Stock | |
| 200 mg | $789 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $80 | In Stock | In Stock |
| Description | DDO-5936 is a potent and specific inhibitor of the protein-protein interaction (PPI) between HSP90 and Cdc37. |
| In vitro | DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor through binding to a critical site on HSP90 involving Glu47. |
| In vivo | DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 decreased tumor cells in the xenografts significantly in high dose group. |
| Molecular Weight | 495.59 |
| Formula | C25H29N5O4S |
| Cas No. | 2355377-13-6 |
| Smiles | Cc1cc(C)c(c(C)c1)S(=O)(=O)N(CC(O)=O)c1ccc(Nc2ccnc(n2)N2CCCC2)cc1 |
| Relative Density. | 1.361 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 6 mg/mL (12.11 mM), Sonication is recommended. | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.02 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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