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ISOPIMPINELLIN

Name: ISOPIMPINELLIN
Brand: TargetMol
SKU: T4593
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4593Cas No. 482-27-9

Alias 5,8-Dimethoxypsoralen, 4,9-Dimethoxypsoralen

Isopimpinellin (4,9-Dimethoxypsoralen) is a natural product isolated from the roots of Pimpinella saxifrage with antiviral and antileishmanial activity.

ISOPIMPINELLIN

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Purity: 99.71%

Catalog No. T4593Alias 5,8-Dimethoxypsoralen, 4,9-DimethoxypsoralenCas No. 482-27-9

Isopimpinellin (4,9-Dimethoxypsoralen) is a natural product isolated from the roots of Pimpinella saxifrage with antiviral and antileishmanial activity.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$36	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$78	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$163	-	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

ISOPIMPINELLIN AI Summary

ISOPIMPINELLIN exhibits a wide range of bioactivities. It shows photobinding activity to Poly(dA-dT)-Poly(dA-dT)-DNA in both dark conditions and after UV-A irradiation, with thermal transition temperature shifts (Delta Tm) of 0.5 degrees C in the dark and 1.0 degrees C post-irradiation. The compound produces singlet oxygen upon UV-A exposure, leading to a decrease in absorbance of N,N-dimethyl-p-nitrosoaniline at 440 nm by -5.0%. Its in vitro phototoxicity is low, with LC50 values exceeding 100,000.0 nM against Artemia salina under daylight and UV-irradiation. Pharmacologically, ISOPIMPINELLIN demonstrates diuretic activity in rats at 125 mg/kg with an 84.0% activity level and anti-inflammatory effects against carrageenan-induced edema in rats at 100 mg/kg with a 30.4% activity level. It shows cytotoxicity against human Raji cells at a molar ratio of 1000, with a 60.0% activity rate, and inhibits TPA-induced EBV-early antigen activation in Raji cells across various molar ratios. Additionally, it scavenges NO generation in human Chang liver cells (ratio of 1.4). ISOPIMPINELLIN inhibits several enzymes, including Human Jumonji Domain Containing 2E (JMJD2E), HPGD, DNA Polymerase Beta, GCN5L2, TDP-43, TDP1, APE1, and the recombinant human BACE1 enzyme, affecting a range of cellular processes from DNA repair to epigenetic regulation. It acts as an activator and inhibitor of Cytochrome P450 3A4 with an associated potency of 1995.3 nM. The compound inhibits the uptake of sodium fluorescein in OATP1B1- and OATP1B3-transfected CHO cells. Additionally, the compound exhibits cytotoxicity against human PC3 cells with an IC50 of 99800.0 nM, inhibits zymosan-induced oxidative burst in blood, and has antimicrobial activity against various microorganisms. It inhibits key cytochrome P450 enzymes, including CYP1A1, CYP1B1, and CYP1A2, indicating its broad inhibitory effects on drug metabolism pathways. Moreover, ISOPIMPINELLIN shows antiviral activity against SARS-CoV-2 and possesses antibacterial activity against norfloxacin-resistant Staphylococcus aureus strains. Overall, ISOPIMPINELLIN demonstrates a versatile profile, impacting photobinding, enzyme inhibition, cytotoxicity, anti-inflammatory, antimicrobial, and antiviral activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isopimpinellin (4,9-Dimethoxypsoralen) is a natural product isolated from the roots of Pimpinella saxifrage with antiviral and antileishmanial activity.
Synonyms	5,8-Dimethoxypsoralen, 4,9-Dimethoxypsoralen

Chemical Properties

Molecular Weight	246.22
Formula	C₁₃H₁₀O₅
Cas No.	482-27-9
Smiles	COc1c2ccoc2c(OC)c2oc(=O)ccc12
Relative Density.	1.352g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.8 mg/mL (112.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0614 mL	20.3070 mL	40.6141 mL	203.0704 mL
5 mM	0.8123 mL	4.0614 mL	8.1228 mL	40.6141 mL
10 mM	0.4061 mL	2.0307 mL	4.0614 mL	20.3070 mL
20 mM	0.2031 mL	1.0154 mL	2.0307 mL	10.1535 mL
50 mM	0.0812 mL	0.4061 mL	0.8123 mL	4.0614 mL
100 mM	0.0406 mL	0.2031 mL	0.4061 mL	2.0307 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc